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Chromosomal Aberrations and Bipolar Affective Disorder

Published online by Cambridge University Press:  02 January 2018

Nick Craddock  and
Mike Owen
Nick Craddock*
Affiliation:
Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN
Mike Owen
Affiliation:
Departments of Psychological Medicine and Medical Genetics, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN
*
∗Department of Psychiatry, Washington University School of Medicine, Jewish Hospital of St Louis, 216 South Kingshighway Blvd, St Louis, MO 63110, USA
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Abstract

Chromosomal abnormalities associated with bipolar disorder may help in the localisation of susceptibility genes for bipolar illness by pinpointing ‘candidate’ regions of the genome for further study using molecular genetic methods. We review descriptions of chromosomal abnormalities in association with bipolar and related affective disorders and evaluate their relevance for localising susceptibility genes for bipolar disorder, using standardised criteria. We found 28 reports. We identified four genomic regions of potential interest: 11q21-25; 15q11-13; chromosome 21; Xq28. It is important that clinicians are able to recognise patients who may have chromosome abnormalities which could help in the localisation of susceptibility genes for psychiatric disorders. We suggest referral for specialist investigation and karyotyping, to a psychiatric genetics research group, of any patient with functional psychosis and one or more of the following: (a) a strong family history of functional psychosis; (b) mental retardation; (c) another disease known to be caused by a single gene; or (d) congenital abnormalities.

Type
Papers
Information
The British Journal of Psychiatry , Volume 164 , Issue 4 , April 1994 , pp. 507 - 512
Copyright
Copyright © 1994 The Royal College of Psychiatrists 

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References

Adams, G. L., Kivowitz, J. & Ziskind, E. (1970) Manic depressive psychosis, mental retardation, and chromosomal rearrangement. Archives of General Psychiatry, 23, 305–309.CrossRefGoogle ScholarPubMed
Bassett, A. S. (1992) Chromosomal aberration and schizophrenia. Autosomes. British Journal of Psychiatry, 161, 323–334.CrossRefGoogle ScholarPubMed
Christensen, K. R., Friedrich, U., Jacobsen, P., et al (1970) Ring chromosome 18 in a mother and daughter. Journal of Mental Deficiency Research, 14, 49–67.Google Scholar
Clarke, D. J. (1993) Prader-Willi syndrome and psychoses: three case reports. British Journal of Psychiatry, 163, 680–684.CrossRefGoogle Scholar
Collacott, R. A., Cooper, S. A. & McGrother, C. (1992) Differential rates of psychiatric disorders in adults with Down's syndrome compared to other mentally handicapped adults. British Journal of Psychiatry, 161, 671–674.CrossRefGoogle ScholarPubMed
Collins, F. S. (1992) Positional cloning: Let's not call it reverse anymore. Nature Genetics, 1, 3–6.CrossRefGoogle Scholar
Cook, E. H. & Leventhal, B. H. (1987) Down's syndrome with mania. British Journal of Psychiatry, 150, 249–250.CrossRefGoogle ScholarPubMed
Cooper, S.-A. & Collacott, R. A. (1991) Manic episodes in Down's syndrome; two case reports. Journal of Nervous and Mental Disease, 179, 635–636.CrossRefGoogle ScholarPubMed
Craddock, N. & McGuffin, P. (1993) Approaches to the genetics of affective disorder. Annals of Medicine, 25, 317–322.Google Scholar
Craddock, N. Krishnan, V. H. R., Prasher, V. P., et al (1993) Major affective disorder associated with duplication of the distal long arm of chromosome 11. Psychiatric Genetics, 3, 149. (Abstract.) Google Scholar
Crandall, B. F., Carrell, R. E., Adams, G. L., et al (1970) Cytogenetic studies in a patient with a de novo t(Cq –;Gp +). Journal of Medical Genetics, 7, 413–416.Google Scholar
Crow, T. J. (1988) Sex chromosomes and psychosis. The case for a pseudoautosomal locus. British Journal of Psychiatry, 153, 675–683.Google Scholar
El-Badramany, M. H., Farag, T. I., Al-Awadi, S. A., et al (1989) Familial manic–depressive illness with deleted short arm of chromosome 21: coincidental or causal? British Journal of Psychiatry, 155, 856–857.CrossRefGoogle ScholarPubMed
Fishbain, D. A. & Vilasuso, A. (1981) Manic-depressive illness associated with Turner's syndrome mosaicism. Journal of Nervous and Mental Disease, 169, 459–461.Google Scholar
Holland, T. & Gosden, C. (1990) A balanced chromosomal translocation partially co-segregating with psychotic illness in a family. Psychiatry Research, 32, 1–8.Google Scholar
Jancar, J. (1968) XXYY with manic–depression. Lancet, ii, 970.CrossRefGoogle Scholar
Jeffries, F. M., Reiss, A. L., Brown, W. T., et al (1993) Bipolar spectrum disorder and fragile X syndrome: a family study. Biological Psychiatry, 33, 213–216.CrossRefGoogle ScholarPubMed
Kerbeshian, J., Burd, L., Randall, T., et al (1990) Autism, profound mental retardation and atypical bipolar disorder in a 33-year-old female with a deletion of 15q12. Journal of Mental Deficiency Research, 34, 205–210.Google Scholar
Krag-Olsen, B., Brask, B. H., Jacobsen, P., et al (1981) Is there an increased risk of psychoses in patients with ring 18 and deletion long arm 18? In Human Behaviour and Genetics (eds Schmid, W. & Nielsen, J.), pp. 211–220. Amsterdam: Elsevier.Google Scholar
Lund, J. (1985) The prevalence of psychiatric morbidity in mentally retarded adults. Acta Psychiatrica Scandinavica, 72, 563–570.CrossRefGoogle ScholarPubMed
Lund, J. (1988) Psychiatric aspects of Down's syndrome. Acta Psychiatrica Scandinavica, 78, 369–374.Google Scholar
McLaughlin, M. (1987) Bipolar affective disorder in Down's syndrome. British Journal of Psychiatry, 151, 116–117.Google Scholar
Mendlewicz, J. & Hirsch, D. (1991) Bipolar manic depressive illness and fragile X syndrome. Biological Psychiatry, 29, 295–308.Google Scholar
Myers, B. A. & Pueschel, S. M. (1991) Psychiatric disorders in persons with Down syndrome. Journal of Nervous and Mental Disease, 179, 609–613.Google Scholar
Nielsen, J., Hreidarsson, A. B. & Christensen, K. R. (1973) D/D translocations in patients with mental illness. Hereditas, 75, 131–135.Google Scholar
Panzer, M. J. & Tandon, R. (1991) Bipolar disorder associated with Turner's syndrome. Journal of Nervous and Mental Disease, 179, 702.Google Scholar
Reid, A. H. (1972) Psychoses in adult mental defectives: I. Manic–depressive psychosis. British Journal of Psychiatry, 120, 205–212.Google Scholar
Reiss, A. L., Feinstein, C., Toomey, K. E., et al (1986) Psychiatric disability associated with the fragile X chromosome. American Journal of Medical Genetics, 23, 393–401.Google Scholar
Reiss, A. L., Freund, L., Abrams, M. T., et al (1993) Neurobehavioral effects of the fragile X premutation in adult women: a controlled study. American Journal of Human Genetics, 52, 884–894.Google Scholar
Reiss, A. L., Hagerman, R. J., Vinogradov, S., et al (1988) Psychiatric disability in female carriers of the fragile X chromosome. Archives of General Psychiatry, 45, 25–30.CrossRefGoogle ScholarPubMed
Roberts, S. H., Cowie, V. A. & Singh, K. R. (1986) Intrachromosomal insertion of chromosome 13 in a family with psychosis and mental subnormality. Journal of Mental Deficiency Research, 30, 227–232.Google Scholar
Smith, M., Wasmuth, J., Mcpherson, J. D., et al (1989) Co-segregation of an 11q22.3-9p22 translocation with affective disorder: proximity of the dopamine D2 receptor gene relative to the translocation breakpoint. American Journal of Medical Genetics, 45, A220.Google Scholar
St Clair, D., Blackwood, D., Muir, W., et al (1990) Association within a family of a balanced autosomal translocation with major mental illness. Lancet, 336, 13–16.Google Scholar
Sovner, R. (1991) Divalproex-responsive rapid cycling bipolar disorder in a patient with Down's syndrome: implications for the Down's syndrome-mania hypothesis. Journal of Mental Deficiency Research, 35, 171–173.Google Scholar
Sovner, R., Hurley, A. D. & Labrie, R. (1984) Is mania incompatible with Down's syndrome? British Journal of Psychiatry, 146, 319–320.Google Scholar
Therman, E. & Susman, M. (1993) Human Chromosomes, Structure, Behaviour, and Effects. New York: Springer-Verlag.Google Scholar
Tranebjaerg, L. & Orum, A. (1991) Major depressive disorder as a prominent but underestimated feature of fragile X syndrome. Comprehensive Psychiatry, 32, 83–87.Google Scholar
Woodhouse, W. J., Holland, A. J., McLean, G., et al (1992) The association between triple X and psychosis. British Journal of Psychiatry, 101, 554–557.Google Scholar
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