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Evidence Against Maternal Influenza as a Risk Factor for Schizophrenia

Published online by Cambridge University Press:  02 January 2018

J.-P. C. J. Selten*
Affiliation:
Rosenburg Psychiatric Hospital, PO Box 53019, 2505 AA The Hague, The Netherlands
J. P. J. Slaets
Affiliation:
Leyenburg Hospital, The Hague, The Netherlands
*
Correspondence

Abstract

We tested the hypothesis that second-trimester exposure to influenza is a risk factor for schizophrenia in the child. The dates of birth of Dutch schizophrenic in-patients were examined for any effect of the 1957 A2 influenza epidemic. Individuals who were in their second trimester of foetal life at the peak of the epidemic were at no greater risk of developing schizophrenia than controls. As the present study has a larger sample size than all previous European studies, and is supported by a large study in the USA, it provides strong evidence against the hypothesis that second-trimester exposure to influenza is a risk factor for schizophrenia.

Type
Short Papers
Copyright
Copyright © 1994 The Royal College of Psychiatrists 

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References

Adams, W., Kendell, R. E., Hare, E. H., et al (1993) Epidemiological evidence that maternal influenza contributes to the aetiology of schizophrenia. An analysis of Scottish, English and Danish data. British Journal of Psychiatry, 163, 522534.CrossRefGoogle Scholar
Barr, C. E., Mednick, S. A. & Munk-Jørgensen, P. (1990) Exposure to influenza epidemics during gestation and adult schizophrenia. Archives of General Psychiatry, 47, 869874.Google Scholar
Cooper, S. J. (1992) Schizophrenia after prenatal exposure to 1957 A2 influenza epidemic. British Journal of Psychiatry, 161, 394396.CrossRefGoogle ScholarPubMed
Crow, T. J., Done, D. J. & Johnstone, E. C. (1991) Schizophrenia and influenza. Lancet, 338, 116117.CrossRefGoogle Scholar
Crow, T. J., & Done, D. J. (1992) Prenatal exposure to influenza does not cause schizophrenia. British Journal of Psychiatry, 161, 390393.CrossRefGoogle ScholarPubMed
Mednick, S. A., Machon, R. A., Huttenen, M. O., et al (1988) Adult schizophrenia following prenatal exposure to an influenza epidemic. Archives of General Psychiatry, 45, 189192.Google Scholar
O'Callaghan, E., Sham, P., Takei, N., et al (1991 a) Schizophrenia after prenatal exposure to 1957 A2 influenza epidemic. Lancet, 337, 12481250.CrossRefGoogle Scholar
O'Callaghan, E., Sham, P., Takei, N., et al (1991b) Schizophrenia and influenza. Lancet 338, 118119.Google Scholar
Sham, P., O'Callaghan, E., Takei, N., et al (1992) Schizophrenia following prenatal exposure to influenza epidemics between 1939 and 1960. British Journal of Psychiatry, 160, 461466.CrossRefGoogle ScholarPubMed
Torrey, E. F., Bowler, A. E. & Rawlings, R. (1991) An influenza epidemic and the seasonality of schizophrenic births. In Second World Congress on Viruses and Mental Health (ed. E. Kurstak), pp 109116. New York: Plenum.Google Scholar
World Health Organization (1978) Mental Disorders: Glossary and Guide to their Classification in accordance with the ninth revision of the International Classification of Diseases (ICD–9). Geneva: WHO.Google Scholar
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