Hostname: page-component-8448b6f56d-sxzjt Total loading time: 0 Render date: 2024-04-19T18:50:21.396Z Has data issue: false hasContentIssue false
  • English
  • Français

Combined Chlorpromazine and Electroconvulsive Therapy in Mania

Published online by Cambridge University Press:  02 January 2018

Sudip Sikdar ,
Parmanand Kulhara ,
Ajit Avasthi  and
Hariwir Singh
Sudip Sikdar
Affiliation:
Postgraduate Institute of Medical Education and Research, Chandigarh–160012, India
Parmanand Kulhara*
Affiliation:
Postgraduate Institute of Medical Education and Research, Chandigarh, India
Ajit Avasthi
Affiliation:
Postgraduate Institute of Medical Education and Research, Chandigarh, India
Hariwir Singh
Affiliation:
Postgraduate Institute of Medical Education and Research, Chandigarh, India
*
∗Correspondence
Get access Rights & Permissions [Opens in a new window]

Abstract

We report the efficacy of combined chlorpromazine and electroconvulsive therapy (ECT) in the treatment of mania. Two groups of 15 manic patients received eight ECT sessions either actual or simulated, in a double-blind, controlled study. All patients also received 600 mg of chlorpromazine daily until the sixth session. Results indicate that the group receiving the combination of chlorpromazine and ECT did significantly better than the other group.

Type
Papers
Information
The British Journal of Psychiatry , Volume 164 , Issue 6 , June 1994 , pp. 806 - 810
Copyright
Copyright © 1994 The Royal College of Psychiatrists 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Abraham, K. R. & Kulhara, P. (1987) The efficacy of electroconvulsive therapy in the treatment of schizophrenia: a comparative study. British Journal of Psychiatry, 151, 152–155.CrossRefGoogle ScholarPubMed
Alexander, R. C., Salmon, M., Ionescu-Pioggia, M. & Cole, J. O. (1988) Convulsive therapy in the treatment of mania: McLean Hospital 1973–1986. Convulsive Therapy, 4, 115–125.Google Scholar
American Psychiatric Association (1987) Diagnostic and Statistical Manual of Mental Disorders (3rd edn, revised) (DSM–III–R). Washington, DC: APA.Google Scholar
Bech, P., Bolwig, T. G., Kramp, P. & Rafaelsen, O. J. (1979) The Bech-Rafaelsen Mania Scale and Hamilton Depression Scale. Acta Psychiatrica Scandinavica, 59, 420–430.Google Scholar
Black, D. W., Winokur, G. & Nasrallah, A. (1987) A naturalistic study of electroconvulsive therapy versus lithium in 460 patients. Journal of Clinical Psychiatry, 48, 132–139.Google Scholar
Bolwig, T. G. (1984) The influence of electrically induced seizures on deep brain structure. In ECT: Brain Mechanisms (eds Larsen, B., Weiner, R. D. & Belmaker, R. H.), pp. 132–138. London: John Libbey.Google Scholar
Bolwig, T. G. (1988) Blood-brain barrier studies with special reference to epileptic seizures. Acta Psychiatrica Scandinavica, 78 (supplement 345), 15–20.Google Scholar
Brandon, S., Cowley, P., McDonald, C., et al (1985) Leicester ECT trial: results in schizophrenia. British Journal of Psychiatry, 146, 177–183.Google Scholar
Friedel, R. O. (1986) The combined use of neuroleptics and ECT in drug resistant schizophrenic patients. Psychopharmacology Bulletin, 22, 928–930.Google Scholar
Gujaverty, K., Greenberg, L. B. & Fink, M. (1987) Electroconvulsive therapy and neuroleptic medication in therapy resistant positive symptom psychosis. Convulsive Therapy, 3, 185–195.Google Scholar
Ipastato, D. J. & Almansi, R. J. (1943) A study of over two thousand cases of electrofit treated patients. New York State Journal of Medicine, 43, 2057–2063.Google Scholar
Janakiramaiah, M., Channabasavanna, S. M. & Murthy, N. S. (1982) ECT/chlorpromazine combination versus chlorpromazine alone in acutely schizophrenic patients. Acta Psychiatrica Scandinavica, 66, 464–470.CrossRefGoogle ScholarPubMed
Kalinowsky, L. B. (1943) Electroconvulsive therapy with emphasis on importance of adequate treatments. Archives of Neurology and Psychiatry, 50, 652–660.Google Scholar
Kemp, H. W. (1945) Electroshock therapy in a state hospital. Minnesota Medicine, 28, 294–296.Google Scholar
Kino, F. F. & Thorpe, F. T. (1946) Electrical convulsive therapy in 500 selected psychotics. Journal of Mental Science, 92, 138–145.CrossRefGoogle Scholar
Kukopuolous, A., Caliari, B., Tondo, A., et al (1983) Rapid cyder, temperament and antidepressants. Comprehensive Psychiatry, 24, 249–258.Google Scholar
McCabe, M. S. (1976) ECT in the treatment of mania: a controlled study. American Journal of Psychiatry, 133, 688–691.Google Scholar
McCabe, M. S. & Norris, B. (1977) ECT versus chlorpromazine in mania. Biological Psychiatry, 12, 245–254.Google Scholar
Mukherjee, S. (1989) Mechanisms of the antimanic effect of electroconvulsive therapy. Convulsive Therapy, 5, 227–243.Google ScholarPubMed
Mukherjee, S. & Debsikdar, V. (1992) Unmodified electroconvulsive therapy of acute mania: a retrospective naturalistic study. Convulsive Therapy, 8, 5–11.Google Scholar
Mukherjee, S., Sackeim, H. A. & Lee, C. (1988) Unilateral ECT in the treatment of manic episodes. Convulsive Therapy, 4, 74–80.Google ScholarPubMed
Overall, J. E. & Gorham, D. R. (1962) The Brief Psychiatric Rating Scale. Psychological Reports, 10, 798–812.Google Scholar
Small, J. G., Klapper, M. H., Kellams, J. J., et al (1988) Electroconvulsive therapy compared with lithium in the management of manic states. Archives of General Psychiatry, 45, 727–732.Google Scholar
Smith, K., Surphlis, W. R. P., Gynther, M. D., et al (1967) ECT-chlorpromazine and chlorpromazine compared in the treatment of schizophrenia. Journal of Nervous and Mental Disease, 144, 284–292.Google Scholar
Smith, L. H., Hastings, D. W. & Hughes, H. (1941) Immediate and follow-up results of electroshock therapy. American Journal of Psychiatry, 98, 558–561.CrossRefGoogle Scholar
Smith, L. H., Hughes, H., Hastings, D. W., et al (1943) Electroshock therapy in the psychoses. American Journal of Psychiatry, 100, 284–290.Google Scholar
Stromgren, L. S. (1988) Electroconvulsive therapy in Aarhus, Denmark, in 1984: its application in nondepressive disorders. Convulsive Therapy, 4, 306–313.Google Scholar
Taylor, P. J. & Fleminger, J. J. (1980) ECT for schizophrenia. Lancet, ii, 1380–1382.CrossRefGoogle ScholarPubMed
Thomas, J. & Reddy, B. (1982) The treatment of mania: a retrospective evaluation of ECT, chlorpromazine and lithium. Journal of Affective Disorders, 4, 85–92.Google Scholar
Thorpe, F. T. (1947) Intensive electrical convulsion therapy in acute mania. Journal of Mental Science, 93, 89–92.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.