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Cerebral Hemiatrophy and Schizophrenia

Published online by Cambridge University Press:  02 January 2018

B. K. Puri ,
A. D. Hall  and
S. W. Lewis
B. K. Puri*
Affiliation:
Charing Cross and Westminster Medical School, London
A. D. Hall
Affiliation:
Severalls Hospital, Colchester
S. W. Lewis
Affiliation:
Charing Cross and Westminster Medical School, London
*
Dr Puri, Department of Psychiatry, Charing Cross and Westminster Medical School, St Dunstan's Road, London W6 8RP
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Abstract

Background

Neuroimaging of a treatment-resistant patient with schizophrenia revealed the existence of cerebral hemiatrophy. The association of schizophrenia with cerebral hemiatrophy has not previously been reported.

Results

Neuroimaging with X-ray computerised tomography showed marked reduction in the volume of the left cerebral hemisphere with secondary enlargement of the left lateral fissure and cortical sulci. High resolution cranial single-photon emission computerised tomography showed a functional deficit of the regional cerebral blood flow in the left lateral parietal and left temporal lobes.

Conclusions

Cerebral hemiatrophy may belong to the lengthening list of neurodevelopmental cerebral anomalies associated with schizophrenia.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 165 , Issue 3 , September 1994 , pp. 403 - 405
Copyright
Copyright © Royal College of Psychiatrists, 1994 

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References

Brennan, R. E., Stratt, B. J. & Lee, K. F. (1978) Computed tomographic findings in cerebral hemiatrophy. Neuroradiology, 17, 17–20.Google Scholar
Dyke, C. G., Davidoff, L. M. & Masson, C. G. (1933) Cerebral hemiatrophy with homolateral hypertrophy of the skull and sinuses. Surgery, Gynecology and Obstetrics, 57, 588–600.Google Scholar
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Lewis, S. W. (1990) Computerised tomography in schizophrenia 15 years on. British Journal of Psychiatry, 157 (suppl. 9), 16–24.CrossRefGoogle Scholar
O'Callaghan, E., Buckley, P., Redmond, O., et al (1992) Abnormalities of cerebral structure in schizophrenia on magnetic resonance imaging: interpretation in relation to the neurodevelopmental hypothesis. Journal of the Royal Society of Medicine, 85, 227–231.Google Scholar
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