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The Korsakoff Syndrome

Published online by Cambridge University Press:  02 January 2018

Michael D. Kopelman*
Affiliation:
Division of Psychiatry and Psychology, UMDS, Guy's and St Thomas's Hospitals, St Thomas's Campus, London SE1 7EH

Abstract

Background

Investigations of the Korsakoff syndrome by researchers from different disciplines have proliferated in recent years, making it apposite to review the various findings.

Method

This review is based on the author's knowledge of reports in the major clinical and neuropsychological journals, supplemented by Medline searches to update particular subtopics.

Results

The Korsakoff syndrome is defined as a disproportionate impairment in memory, relative to other aspects of cognitive function, resulting from a nutritional (thiamine) depletion. The initial manifestations of the disorder are variable, and a persistent memory impairment can result from a non-alcoholic aetiology, although this seems to happen much less commonly than in the past – presumably because of generally higher standards of nutrition. Although there is agreement on the underlying neuropathology, the critical lesion sites for memory disorder have been debated. Recent evidence suggests that the circuit involving the mammillary bodies, the mammillo-thalamic tract and the anterior thalamus, rather than the medial dorsal nucleus of the thalamus, is particularly critical in the formation of new memories. The relationship of these deficits to thiamine depletion remains a topic of current investigation, as does the purported role of neurotransmitter depletions in the cholinergic, glutamate/GABA and catecholamine and serotonergic systems. Neuro-imaging studies have confirmed autopsy findings of more widespread structural and metabolic abnormalities, particularly involving the frontal lobes.

Conclusions

The relationship of these neuropathological, neurochemical, and metabolic abnormalities to cognitive functioning, with particular reference to specific aspects of memory processing, has been considered in some detail. Whereas structural and/or neurochemical abnormalities within the limbic/diencephalic circuits account for anterograde amnesia, some other factor, such as frontal lobe dysfunction, must underlie the severe retrograde memory loss which is characteristically found in this syndrome.

Type
Review Article
Copyright
Copyright © 1995 The Royal College of Psychiatrists 

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References

Albert, M. S., Butters, N. & Levin, J. (1979) Temporal gradients in the retrograde amnesia of patients with alcoholic Korsakoff's disease. Archives of Neurology, 36, 211216.Google Scholar
Alexander, L. (1940) Wernicke's disease: identity of lesions produced experimentally by B1 avitaminosis in pigeons with haemorrhagic polioencephalitis occurring in chronic alcoholism in man. American Journal of Pathology, 16, 6170.Google ScholarPubMed
Alexander, L., Pijoan, M. & Myerson, A. (1938) Beri-beri and scurvy. Transactions of the American Neurological Association, 64, 135139.Google Scholar
Arendt, T., Biol, V., Arendt, A., et al (1983) Loss of neurons in the nucleus basalis of Meynert in Alzheimer's disease, paralysis agitans and Korsakoff's disease. Acta Neuropathologica, 61, 101108.Google Scholar
Baddeley, A. D. (1986) Working Memory. Oxford: Clarendon Press.Google ScholarPubMed
Baddeley, A. D. (1990) Human Memory: Theory and Practice. London: Lawrence Erlbaum.Google Scholar
Baddeley, A. D. & Warrington, E. K. (1970) Amnesia and the distinction between long- and short-term memory. Journal of Verbal Learning and Verbal Behaviour, 9, 176189.CrossRefGoogle Scholar
Baddeley, A. D. & Wilson, B. (1986) Amnesia, autobiographical memory, and confabulation. In Autobiographical Memory (ed. Rubin, D. C.). Cambridge: Cambridge University Press.Google Scholar
Baddeley, A. D. & Wilson, B. (1994) When implicit learning fails: amnesia and the problem of error elimination. Neuropsychologia, 32, 5368.CrossRefGoogle ScholarPubMed
Barclay, L. L., Gibson, G. E. & Blass, J. P. (1981) Impairment of behaviour and acetylcholine in thiamine deficiency. Journal of Pharmacology and Experimental Therapeutics, 217, 537543.Google ScholarPubMed
Beatty, W. W., Baily, R. C. & Fisher, L. (1989) Korsakoff-like amnesic syndrome in a patient with anorexia and vomiting. International Journal of Clinical Neuropsychology, 11, 5565.Google Scholar
Becker, J. T., Furman, J. M. R., Panisset, M., et al (1990) Characteristics of the memory loss of a patient with Wernicke-Korsakoff's syndrome without alcoholism. Neuropsychologia, 28, 171179.CrossRefGoogle ScholarPubMed
Bender, L. & Schilder, P. (1933) Encephalopathia alcoholica: polioencephalitis haemorrhagica superior of Wernicke. Archives of Neurology and Psychiatry, 29, 9901053.Google Scholar
Berlyne, N. (1972) Confabulation. British Journal of Psychiatry, 120, 3139.Google Scholar
Blass, J. P. & Gibson, G. E. (1977) Abnormality of a thiamine-requiring enzyme in patients with Wernicke-Korsakoff syndrome. New England Journal of Medicine, 297, 13671370.Google Scholar
Bowen, D. M. (1990) Treatment of Alzheimer's disease: molecular pathology versus neurotransmitter-based therapy. British Journal of Psychiatry, 157, 327330.Google Scholar
Bowen, D. M., Francis, P. T., Pangalos, M., et al (1992) Treatment strategies for Alzheimer's disease. Lancet, 339, 132133.CrossRefGoogle ScholarPubMed
Bowman, K. M., Goodhart, R. & Jolliffe, N. (1939) Observations on the role of vitamin B1 in the aetiology and treatment of Korsakoff psychosis. Journal of Nervous and Mental Disease, 90, 569575.CrossRefGoogle Scholar
Brandt, J. & Butters, N. (1986) The alcoholic Wernicke-Korsakoff syndrome and its relationship to long-term alcohol abuse. In Neuropsychological Assessment of Neuropsychiatric Disorders (eds Grant, I. & Adams, K. M.), pp. 441477. Oxford: Oxford University Press.Google Scholar
Brooks, D. N. & Baddeley, A. D. (1976) What can amnesic patients learn? Neuropsychologia, 14, 111122.Google Scholar
Butters, N. (1985) Alcoholic Korsakoff's syndrome: some unresolved issues concerning etiology, neuropathology, and cognitive deficits. Journal of Clinical and Experimental Neuropsychology, 7, 181210.CrossRefGoogle ScholarPubMed
Butters, N. & Cermak, L. S. (1980) Alcoholic Korsakoff's Syndrome: An Information-Processing Approach to Amnesia. New York: Academic Press.Google Scholar
Butters, N., Salmon, D. P., Munro Cullum, C., et al (1988) Differentiation of amnesic and demented patients with the Wechsler Memory Scale – Revised. Clinical Neurologist, 2, 133148.Google Scholar
Campbell, A. C. P. & Russell, W. R. (1941) Wernicke's encephalopathy: the clinical features and their probable relationship to vitamin B deficiency. Quarterly Journal of Medicine, 34, 4164.Google Scholar
Carlen, P. L., Wilkinson, D. A., Wortzman, G., et al (1981) Cerebral atrophy and functional deficits in alcoholics without apparent liver disease. Neurology, 31, 377385.Google Scholar
Castaigne, P., Lhermitte, F., Buge, A., et al (1981) Paramedian thalamic and midbrain infarcts: clinical and neuropathological study. Annals of Neurology, 10, 127148.Google Scholar
Cermak, L. S. (1984) The episodic-semantic distinction in amnesia. In The Neuropsychology of Memory (eds Squire, L. R. & Butters, N.). New York: Guilford Press.Google Scholar
Christie, J. E., Kean, D. M., Douglas, R. H. B., et al (1988) Magnetic resonance imaging in presenile dementia of the Alzheimer-type, multi-infarct dementia, and Korsakoff's syndrome. Psychological Medicine, 16, 319329.Google Scholar
Cohen, N. J. & Squire, L. R. (1981) Retrograde amnesia and remote memory impairment. Neuropsychologia, 19, 337356.CrossRefGoogle ScholarPubMed
Cravioto, H., Korein, J. & Silberman, J. (1961) Wernicke's encephalopathy. Archives of Neurology, 4, 5463.CrossRefGoogle ScholarPubMed
Cruikshank, E. K. (1950) Wernicke's encephalopathy. Quarterly Journal of Medicine, 19, 327338.Google Scholar
Cutler, N. R., Haxby, J., Kay, A. D., et al (1985) Evaluation of zimelidine in Alzheimer's disease. Archives of Neurology, 42, 744748.Google Scholar
Cutting, J. (1978a) The relationship between Korsakoff's syndrome and “alcoholic dementia”. British Journal of Psychiatry, 132, 240251.Google Scholar
Cutting, J. (1978b) A cognitive approach to Korsakoff's syndrome. Cortex, 14, 485495.Google Scholar
Dalla Barba, G. (1993) Confabulation: knowledge and recollective experience. Cognitive Neuropsychology, 10, 120.Google Scholar
Dalla Barba, G., Cipolotti, L. & Denes, G. (1990) Autobiographical memory loss and confabulation in Korsakoff's syndrome: a case report. Cortex, 26, 525534.CrossRefGoogle ScholarPubMed
Damasio, A. R., Graff-Radford, N. R., Eslinger, P. J., et al (1985a) Amnesia following basal forebrain lesions. Archives of Neurology, 42, 263271.Google Scholar
Damasio, A. R., Eslinger, P. J., Damasio, H., et al (1985b) Multimodal amnesic syndrome following bilateral temporal and basal forebrain damage. Archives of Neurology, 42, 252259.Google Scholar
D'Assigny, M. (1697) The art of memory: a treatise useful for such as are to speak in publick. In Three Hundred Years of Psychiatry, (eds Hunter, R. & Macalpine, I., 1963), pp. 262264. Oxford: Oxford University Press.Google Scholar
Dehlin, O., Hedenrud, B., Jansson, P., et al (1985) A double-blind comparison of alaproclate and placebo in the treatment of patients with senile dementia. Acta Psychiatrica Scandinavica, 71, 190196.Google Scholar
Della Sala, S., Laiacona, M., Spinnler, H., et al (1993) Impaired autobiographical recollection in some frontal patients. Neuropsychologia, 31, 823840.Google Scholar
De Renzi, E., Liotti, M. & Nichelli, P. (1987) Semantic amnesia with preservation of autobiographical memory. Cortex, 23, 575597.CrossRefGoogle Scholar
Devathason, G. & Koh, C. (1982) Wernicke's encephalopathy in prolonged fasting. Lancet, 2, 11081109.Google Scholar
De Wardener, H. E. & Lennox, B. (1947) Cerebral beriberi (Wernicke's encephalopathy): review of 52 cases in a Singapore PoW hospital. Lancet, 1, 1117.Google Scholar
Dusoir, H., Kapur, N., Byrnes, D. P., et al (1990) The role of diencephalic pathology in human memory disorder: evidence from a penetrating paranasal injury. Brain, 113, 16951706.CrossRefGoogle ScholarPubMed
Ebels, E. J. (1978) How common is Wernicke-Korsakoff syndrome? Lancet, 2, 781782.CrossRefGoogle ScholarPubMed
Ellison, D. W., Beal, M. F., Mazurek, M. F., et al (1986) A post-mortem study of aminoacid neurotransmitters in Alzheimer's disease. Annals of Neurology, 20, 616621.Google Scholar
Evans, J., Wilson, B., Wright, P. W., et al (1993) Neuropsychological and SPECT scan findings during and after transient global amnesia: evidence for the differential impairment of remote episodic memory. Journal of Neurology, Neurosurgery and Psychiatry, 56, 12271230.Google Scholar
Fazio, F., Perani, D., Gilardi, M. C., et al (1992) Metabolic impairment in human amnesia: a PET study of memory networks. Journal of Cerebral Blood Flow and Metabolism, 12, 353358.CrossRefGoogle ScholarPubMed
Freund, G. (1973) Chronic central nervous system toxicity in alcohol. Annual Review of Pharmacology, 13, 217227.CrossRefGoogle ScholarPubMed
Frith, C. D., Cahill, C., Ridley, R. M., et al (1992) Memory for what it is and memory for what it means: a single case of Korsakoff's amnesia. Cortex, 28, 5367.CrossRefGoogle Scholar
Gabrielli, J. D. E., Cohen, N. J. & Corkin, S. (1988) The impaired learning of semantic knowledge following bilateral medial temporal-lobe resection. Brain and Cognition, 7, 157177.Google Scholar
Gentilini, M., De Renzi, E. & Crisi, G. (1987) Bilateral paramedian thalamic artery infarcts: report of eight cases. Journal of Neurology, Neurosurgery and Psychiatry, 50, 900909.Google Scholar
Gibson, G. E., Jope, R. & Blass, J. P. (1975) Decreased synthesis of acetylcholine accompanying impaired oxidation of pyruvic acid in rat brain minces. Biochemical Journal, 148, 1723.Google Scholar
Glisky, E. L., Schacter, D. & Tulving, E. (1986) Computer learning by memory impaired patients: acquisition and retention of complex knowledge. Neuropsychologia, 24, 313328.Google Scholar
Graf, P., Squire, L. R. & Mandler, G. (1984) The information that amnesic patients do not forget. Journal of Experimental Psychology: Learning, Memory and Cognition, 11, 501518.Google Scholar
Graff-Radford, N. R., Damasio, H., Yamada, T., et al (1985) Non-haemorrhagic thalamic infarction: clinical, neurological, and electrophysiological findings in four anatomical groups defined by computerised tomography. Brain, 408, 485516.Google Scholar
Graff-Radford, N. R., Tranel, D., Van Hoesen, G. W., et al (1990) Diencephalic amnesia. Brain, 113, 126.Google Scholar
Guberman, A. & Stuss, D. (1983) The syndrome of bilateral paramedian thalamic infarction. Neurology, 33, 540546.Google Scholar
Harper, C. G. (1979) Wernicke's encephalopathy: a more common disease than realised: a neuropathological study of 51 cases. Journal of Neurology, Neurosurgery and Psychiatry, 42, 226231.Google Scholar
Harper, C. G. (1980) Sudden, unexpected death and Wernicke's encephalopathy: a complication of prolonged I/V feeding. Australian and New Zealand Journal of Medicine, 10, 230235.Google Scholar
Harper, C. G. (1983) The incidence of Wernicke's encephalopathy in Australia: a neuropathological study of 131 cases. Journal of Neurology, Neurosurgery and Psychiatry, 46, 593598.Google Scholar
Harper, C. G., Kril, J. & Daly, J. (1987) Are we drinking our neurones away? British Medical Journal, 294, 534536.Google Scholar
Harper, C. G., Kril, J. & Daly, J. (1988) Brain shrinkage in alcoholics is not caused by changes in hydration: a pathological study. Journal of Neurology, Neurosurgery and Psychiatry, 51, 124127.CrossRefGoogle ScholarPubMed
Hata, T., Meyer, J. S., Tanahashi, N., et al (1987) Three-dimensional mapping of local cerebral perfusion in alcoholic encephalopathy with and without Wernicke-Korsakoff syndrome. Journal of Cerebral Blood Flow and Metabolism, 7, 3544.Google Scholar
Hirst, W. (1982) The amnesic syndrome: descriptions and explanations. Psychological Bulletin, 91, 435460.Google Scholar
Hodges, J. R., Patterson, K., Oxbury, S., et al (1992) Semantic dementia. Progressive fluent aphasia with temporal lobe atrophy. Brain, 115, 17831806.Google Scholar
Hodges, J. R. & McCarthy, R. A. (1993) Autobiographical amnesia resulting from bilateral paramedian thalamic infarction. A case study in cognitive neurobiology. Brain, 116, 921940.Google Scholar
Hooke, R. (1680) Lectures of light. In Three Hundred Years of Psychiatry: 1535–1860 (eds Hunter, R. & Macalpine, I., 1963). Oxford: Oxford University Press.Google Scholar
Hunter, R., McLuskie, R., Wyper, D., et al (1989) The pattern of function-related regional cerebral blood flow investigated by single photon emission tomography with 99mTc-HMPAO in patients with presenile Alzheimer's disease and Korsakoff's psychosis. Psychological Medicine, 19, 847856.Google Scholar
Huppert, F. A. & Piercy, M. (1976) Recognition memory in amnesic patients: effect of temporal context and familiarity of material. Cortex, 12, 320.Google Scholar
Huppert, F. A. & Piercy, M. (1978a) The role of trace strength in recency and frequency judgements by amnesic and control subjects. Quarterly Journal of Experimental Psychology, 30, 347354.Google Scholar
Huppert, F. A. & Piercy, M. (1978b) Dissociation between learning and remembering in organic amnesia. Nature, 275, 317318.Google Scholar
Hyman, B. T., Van Hoesen, G. W. & Damasio, A. R. (1987) Alzheimer's disease: glutamate depletion in the hippocampal perforant pathway zone. Annals of Neurology, 22, 3740.Google Scholar
Irle, E. & Markowitsch, H. J. (1987) Basal forebrain-lesioned monkeys are severely impaired in tasks of association and recognition memory. Annals of Neurology, 22, 735743.CrossRefGoogle ScholarPubMed
Ishii, N. & Nishihara, Y. (1981) Pellagra among chronic alcoholics – clinical and pathological study of 20 necropsy cases. Journal of Neurology, Neurosurgery and Psychiatry, 44, 209215.Google Scholar
Jacobson, R. R. (1987) Clinical, CAT Scan and Psychometric Studies in Korsakoff's Psychosis. MD Thesis, University of Cambridge.Google Scholar
Jacobson, R. R., Turner, S. W., Baldy, R. E., et al (1985) Densitometric analysis of scans: important sources of artefact. Psychological Medicine, 15, 879889.CrossRefGoogle ScholarPubMed
Jacobson, R. R. & Lishman, W. (1987) Selective memory loss and global intellectual deficits in alcoholic Korsakoff's syndrome. Psychological Medicine, 17, 649655.CrossRefGoogle ScholarPubMed
Jacobson, R. R. & Lishman, W. (1990) Cortical and diencephalic lesions in Korsakoff's syndrome: a clinical and CT scan study. Psychological Medicine, 20, 6375.Google Scholar
Jacobson, R. R., Acker, C. & Lishman, W. A. (1990) Patterns of neuropsychologics deficit in alcoholic Korsakoff's syndrome. Psychological Medicine, 20, 321334.Google Scholar
James, W. (1890) Principles of Psychology, Vol. 1. New York: Holt.Google Scholar
Janowsky, J. S., Shimamura, A. P., Kritchevsky, M., et al (1989) Cognitive impairment following frontal lobe damage and its relevance to human amnesia. Behavioural Neuroscience, 103, 548560.CrossRefGoogle ScholarPubMed
Jernigan, T. L., Schafer, K., Butters, N., et al (1991) Magnetic resonance imaging of alcoholic Korsakoff patients. Neuropsychopharmacology, 4, 175186.Google Scholar
Johnson, M. K. & Kim, J. K. (1985) Do alcoholic Korsakoff's syndrome patients acquire affective reactions? Journal of Experimental Psychology: Learning, Memory and Cognition, 11, 2236.Google Scholar
Jolliffe, N., Wortis, H. & Fein, H. D. (1941) The Wernicke syndrome. Archives of Neurology and Psychiatry, 46, 569597.Google Scholar
Joyce, E. M. & Robbins, T. W. (1991) Frontal lobe function in Korsakoff and non-Korsakoff alcoholics: planning and spatial working memory. Neuropsychologia, 29, 709723.Google Scholar
Jung, E-H., Rex Sheu, K-F. & Blass, J. P. (1993) An enzymatic and immunochemical analysis of transketolase in fibroblasts from Wernicke-Korsakoff syndrome. Journal of Neurological Sciences, 114, 123127.Google Scholar
Kapur, N. & Butters, N. (1977) Visuoperceptive deficits in long-term alcoholics with Korsakoff's psychosis. Journal of Studies on Alcohol, 38, 20252035.Google Scholar
Kapur, N. & Coughlan, A. K. (1980) Confabulation and frontal lobe dysfunction. Journal of Neurology, Neurosurgery and Psychiatry, 43, 461463.Google Scholar
Katz, D. I., Alexander, M. P. & Mandell, A. M. (1987) Dementia following strokes in the mesencephalon and diencephalon. Archives of Neurology, 44, 11271133.Google Scholar
Kopelman, M. D. (1985) Rates of forgetting in Alzheimer-type dementia and Korsakoff's syndrome. Neuropsychologia, 23, 623638.Google Scholar
Kopelman, M. D. (1986a) The cholinergic neurotransmitter system in human memory and dementia: a review. Quarterly Journal of Experimental Psychology, 38A, 535573.Google Scholar
Kopelman, M. D. (1986b) Clinical tests of memory. British Journal of Psychiatry, 148, 517525.Google Scholar
Kopelman, M. D. (1987a) Amnesia: organic and psychogenic. British Journal of Psychiatry, 150, 428442.Google Scholar
Kopelman, M. D. (1987b) Two types of confabulation. Journal of Neurology, Neurosurgery and Psychiatry, 50, 14821487.Google Scholar
Kopelman, M. D. (1989) Remote and autobiographical memory, temporal context memory, and frontal atrophy in Korsakoff and Alzheimer patients. Neuropsychologia, 27, 437460.Google Scholar
Kopelman, M. D. (1991a) Frontal lobe dysfunction and memory deficits in the alcoholic Korsakoff syndrome and Alzheimer-type dementia. Brain, 114, 117137.Google Scholar
Kopelman, M. D. (1991b) Non-verbal, short-term forgetting in the alcoholic Korsakoff syndrome and Alzheimer-type dementia. Neuropsychologia, 29, 737747.Google Scholar
Kopelman, M. D. (1992) The ‘new’ and the ‘old’: components of the anterograde and retrograde memory loss in Korsakoff and Alzheimer patients. In The Neuropsychology of Memory (2nd edn) (eds Squire, L. R. & Butters, N.), pp. 130146. New York: Guilford.Google Scholar
Kopelman, M. D. (1993) The neuropsychology of remote memory. In Handbook of Neuropsychology, Vol. 8 (eds Spinner, H. & Boiler, F.), pp. 215238. Amsterdam: Elsevier.Google Scholar
Kopelman, M. D. & Corn, T. H. (1988) Cholinergic ‘blockade’ as a model for cholinergic depletion: a comparison of the memory deficits with those of Alzheimer-type dementia and the alcoholic Korsakoff syndrome. Brain, 111, 10791110.Google Scholar
Korsakoff, S. S. (1887) Disturbance of psychic function in alcoholic paralysis and its relation to the disturbance of the psychic sphere in multiple neuritis of non-alcoholic origin. Quoted by Victor, M., Adams, R. D. & Collins, G. H. (1971) The Wernicke-Korsakoff Syndrome. Oxford: Blackwell.Google Scholar
Kopelman, M. D. (1889a) Psychic disorder in conjunction with peripheral neuritis (trans. M. Victor & P. I. Yakovlev, 1955). Neurology, 5, 394406.Google Scholar
Kopelman, M. D. (1889b) Etude médico-psychologique sur une forme des maladies de la mémoire. Revue Philosophic, 20, 501530.Google Scholar
Kraepelin, E. (1910) Psychiatrie (8th edn). Leipzig: Barth.Google Scholar
Lawlor, B. A., Mellow, A. M., Sunderland, T., et al (1988) A pilot study of serotonergic system responsivity in Alzheimer's disease. Psychopharmacology Bulletin, 24, 127129.Google Scholar
Lawson, R. (1878) On the symptomatology of alcoholic brain disorders. Brain, 1, 182194.CrossRefGoogle Scholar
Leigh, D., McBurney, A. & McIlwain, H. (1981) Erythrocyte transketolase activity in the Wernicke-Korsakoff syndrome. British Journal of Psychiatry, 139, 153156.Google Scholar
Leng, N. R. C. & Parkin, A. J. (1988) Double dissociation of frontal dysfunction in organic amnesia. British Journal of Clinical Psychology, 27, 359362.CrossRefGoogle ScholarPubMed
Leng, N. R. C. & Parkin, A. J. (1989) Aetiological variation in the amnesic syndrome: comparisons using the Brown-Peterson task. Cortex, 25, 251259.Google Scholar
Lishman, W. A. (1981) Cerebral disorder in alcoholism: syndromes of impairment. Brain, 104, 120.Google Scholar
Luda, E. (1980) Wernicke's encephalopathy. Archives of Neurology, 37, 255.Google Scholar
Luria, A. R. (1976) The Neuropsychology of Memory. New York: John Wiley.Google Scholar
Lynch, G. & Baudry, M. (1988) Structure-function relationships in the organization of memory. In Perspectives in Memory Research (ed. Gazzaniga, M. S.), pp. 2391. Cambridge, MA: Massachusetts Institute of Technology Press.Google Scholar
MacAndrew, S. B. G. & Jones, G. V. (1993) Spatial memory in amnesia: evidence from Korsakoff patients. Cortex, 29, 235250.Google Scholar
Mair, R. G. & McEntee, W. J. (1983) Korsakoff's psychosis: noradrenergic systems and cognitive impairment. Behavioural Brain Research, 9, 132.Google Scholar
Mair, R. G. & McEntee, W. J. (1986) Cognitive enhancement in Korsakoff's psychosis by clonidine: a comparison with L-dopa and ephedrine. Psychopharmacology, 88, 374380.Google Scholar
Mair, W. G. P., Warrington, E. K. & Weiskrantz, L. (1979) Memory disorder in Korsakoff's psychosis: a neuropathological and neuropsychological investigation of two cases. Brain, 102, 749783.Google Scholar
Malamud, N. & Skillicorn, S. A. (1956) Relationship between the Wernicke and Korsakoff syndrome. Archives of Neurology and Psychiatry, 76, 585596.Google Scholar
Markowitsch, H. J. (1984) Can amnesia be caused by damage of a single brain structure? Cortex, 20, 2745.Google Scholar
Martin, P. R., Weingartner, H., Gordon, E. K., et al (1984) Central nervous system catecholamine metabolism in Korsakoff's psychosis. Annals of Neurology, 15, 184187.Google Scholar
Martin, P. R., Adinoff, B., Eckardt, M. J., et al (1989) Effective pharmacotherapy of alcoholic amnesic disorder with fluvoxamine. Archives of General Psychiatry, 46, 617621.CrossRefGoogle Scholar
Martin, P. R., Rio, D., Adinoff, B., et al (1992) Regional cerebral glucose utilization in chronic organic mental disorders associated with alcoholism. Journal of Neuropsychiatry and Clinical Neurosciences, 4, 159167.Google Scholar
Martone, M., Butters, N., Payne, M., et al (1984) Dissociations between skill learning and verbal recognition in amnesia and dementia. Archives of Neurology, 41, 965970.Google Scholar
Martone, M. & Trauner, D. (1986) Some analyses of forgetting of pictorial material in amnesic and demented patients. Journal of Clinical and Experimental Neuropsychology, 8, 161178.Google Scholar
Mattis, S. (1976) Dementia Rating Scale. In Geriatric Psychiatry 1 (eds Bellack, R. & Karasu, B.). New York: Grune & Stratton.Google Scholar
Mayes, A. R. (1988) Human Organic Memory Disorders. Cambridge: Cambridge University Press.Google Scholar
Mayes, A. R. (1992) What are the functional deficits that underlie amnesia? In The Neuropsychology of Memory (2nd edn) (eds Squire, L. R. & Butters, N.), pp. 2335. New York: Guilford.Google Scholar
Mayes, A. R., Meudell, P. R. & Pickering, A. (1985) Is organic amnesia caused by a selective deficit in remembering contextual information? Cortex, 21, 167202.Google Scholar
Mayes, A. R., Meudell, P. R., Mann, D., et al (1988) Location of lesions in Korsakoff's syndrome: neuropsychological and neuropathological data on two patients. Cortex, 24, 367388.Google Scholar
Mayes, A. R., Meudell, P. R. & MacDonald, C. (1991) Disproportionate intentional spatial memory impairments in amnesia. Neuropsychologia, 29, 771784.Google Scholar
McCool, B. A., Plonk, S. G., Martin, P. R., et al (1993) Cloning of human transketolase cDNAs and comparison of the nucleotide sequence of the coding region in Wernicke-Korsakoff and non-Wernicke-Korsakoff individuals. Journal of Biological Chemistry, 268, 13971404.Google Scholar
McDowell, J. (1981) Effects of encoding instructions on recall and recognition in Korsakoff patients. Neuropsychologia, 19, 4348.Google Scholar
McDowell, J. & Le Blanc, H. J. (1984) Computed tomographic findings in the Wernicke-Korsakoff syndrome. Archives of Neurology, 41, 453454.Google Scholar
McEntee, W. J. (1993) The effect of ethanol on thiamine absorption and metabolism: a possible explanation for so-called alcoholic dementia. British Association of Psychopharmacology Annual Meeting Abstracts, p. A6.Google Scholar
McDowell, J., Biber, M. P., Perl, D. P., et al (1976) Diencephalic amnesia: reappraisal. Journal of Neurology, Neurosurgery and Psychiatry, 39, 436441.Google Scholar
McDowell, J. & Mair, R. G. (1978) Memory impairment in Korsakoff's psychosis: a correlation with brain noradrenergic activity. Science, 202, 905907.Google Scholar
McDowell, J. & Mair, R. G. (1979) Memory enhancement in Korsakoff's psychosis by clonidine: further evidence for a noradrenergic deficit. Annals of Neurology, 7, 466470.Google Scholar
McDowell, J., Mair, R. G. & Langlais, P. J. (1984) Neurochemical pathology in Korsakoff's psychosis: implications for other cognitive disorders. Neurology, 34, 648652.Google Scholar
Mensing, J. W. A., Hoogland, P. H. & Sloof, J. L. (1984) Computed tomography in the diagnosis of Wernicke's encephalography – a radiological-neuropathological correlation. Annals of Neurology, 16, 363365.Google Scholar
Meudell, P. & Mayes, A. R. (1982) Normal and abnormal forgetting: some comments on the human amnesic syndrome. In Normality and Pathology in Cognitive Functions (ed. Ellis, A. W.), pp. 203208. London: Academic Press.Google Scholar
Meudell, P. & Mayes, A. R., Ostergaard, A., et al (1985) Recency and frequency judgements in alcoholics amnesics and normal people with poor memory. Cortex, 21, 487511.Google Scholar
Meunier, M., Bachevalier, J., Mishkin, M., et al (1993) Effects on visual recognition of combined and separate ablations of the entorhinal and perirhinal cortex in rhesus monkeys. Journal of Neuroscience, 13, 54185432.Google Scholar
Milner, B. (1966) Amnesia following operation on the temporal lobes. In Amnesia (eds Whitty, C. W. M. & Zangwill, O.), pp. 109133. London: Butterworths.Google Scholar
Mishkin, M. (1978) Memory in monkeys is severely impaired by combined but not by separate removal of amygdala and hippocampus. Nature, 273, 297298.Google Scholar
Mishkin, M. (1982) A memory system in the monkey. Philosophical Transactions of the Royal Society, London, B298, 8595.Google Scholar
Moll, J. M. (1915) The amnesic or Korsakoff's syndrome with alcoholic aetiology: an analysis of 30 cases. Journal of Mental Science, 61, 423437.Google Scholar
Mori, E., Yamadoris, A. & Mitani, Y. (1986) Left thalamic infarction and disturbance of verbal memory: a clinicoanatomical study with a new method of computed tomographic stereotaxis lesion localisation. Annals of Neurology, 20, 671676.Google Scholar
Moscovitch, M. (1982) Multiple dissociation of function in amnesia. In Human Memory and Amnesia (ed. Cermak, L. S.), pp. 337370. Hillsdale, NJ: Lawrence Erlbaum.Google Scholar
Murray, E. A., Gaffan, D. & Mishkin, M. (1993) Neural substrates of visual stimulus-stimulus association in rhesus monkeys. Journal of Neuroscience, 13, 45494561.Google Scholar
Nightingale, S., Bates, D., Heath, P. D., et al (1982) Wernicke's encephalopathy in hyperemesis gravidarum. Postgraduate Medical Journal, 58, 558559.Google Scholar
Nixon, P. F., Kaczmarek, M. J., Tate, J., et al (1984) An erythrocyte transketolase isoenzyme pattern associated with the Wernicke-Korsakoff syndrome. European Journal of Clinical Investigation, 14, 278281.Google Scholar
O'Carroll, R. E., Moffoot, A., Ebmeier, K. P., et al (1993) Korsakoff's syndrome, cognition and clonidine. Psychological Medicine, 23, 341348.Google Scholar
O'Connor, M., Butters, N., Miliotis, P., et al (1992) The dissociation of anterograde and retrograde amnesia in a patient with herpes encephalitis. Journal of Clinical and Experimental Neuropsychology, 14, 159178.Google Scholar
O'Donnell, V. M., Pitts, W. M. & Fann, W. E. (1986) Noradrenergic and cholinergic agents in Korsakoff's syndrome. Clinical Neuropharmacology, 9, 6570.Google Scholar
Ogden, J. A. (1993) Visual object agnosia, prosopagnosia, achromatopsia, loss of visual imagery, and autobiographical amnesia following recovery from cortical blindness: case MH. Neuropsychologia, 31, 571589.Google Scholar
Oscar-Berman, M. (1973) Hypothesis testing and focusing behavior during concept formation for amnesic Korsakoff patients. Neuropsychologia, 11, 191198.Google Scholar
Parkin, A. J. (1991) Recent advances in the neuropsychology of memory. In Memory: Neurochemical and Abnormal Perspectives (eds Weinman, J. & Hunter, J.), pp. 141162. London: Harwood.Google Scholar
Parkin, A. J. (1992) Functional significance of aetiological factors in human amnesia. In The Neuropsychology of Memory (2nd edn) (eds Squire, L. R. & Butters, N.), pp. 122129. New York: Guilford.Google Scholar
Parkin, A. J., Montaldi, D., Leng, N. R. C., et al (1990) Contextual cueing effects in the remote memory of alcoholic Korsakoff patients and normal subjects. Quarterly Journal of Experimental Psychology, 42A, 585596.Google Scholar
Parkin, A. J., Blunden, J., Rees, J. E., et al (1991) Wernicke -Korsakoff syndrome of nonalcoholic origin. Brain and Cognition, 15, 6982.Google Scholar
Parkin, A. J. & Hunkin, N. M. (1993) Impaired temporal context memory on anterograde but not retrograde tests in the absence of frontal pathology. Cortex, 29, 267280.Google Scholar
Parkin, A. J., Rees, J. E., Hunkin, N. M., et al (1994) Impairment of memory following discrete thalamic infarction. Neuropsychologia, 32, 3952.Google Scholar
Pentland, B. & Mawdsley, C. (1982) Wernicke's encephalopathy following ‘hunger strike’. Postgraduate Medical Journal, 58, 427428.Google Scholar
Perani, D., Bressi, S., Cappa, S. F., et al (1993) Evidence of multiple memory systems in the human brain. A [18F]FDG PET metabolic study. Brain, 116, 903920.Google Scholar
Phillips, S., Sangalang, V. & Sterns, G. (1987) Basal forebrain infarction – a clinicopathological correlation. Archives of Neurology, 44, 11341138.CrossRefGoogle Scholar
Pickering, A., Mayes, A. R. & Fairbairn, A. F. (1989) Amnesia and memory for modality information. Neuropsychologia, 27, 12491259.Google Scholar
Riggs, H. E. & Boles, R. S. (1944) Wernicke's disease: a clinical and pathological study of 42 cases. Quarterly Journal of Studies on Alcohol, 5, 361370.Google Scholar
Robbins, T. W. (1984) Cortical noradrenaline, attention, and arousal. Psychological Medicine, 14, 1321.Google Scholar
Roedigger, H. L. & Blaxton, T. A. (1987) Retrieval modes produce dissociations in memory for surface information. In Memory and Cognitive Processes: The Ebbinghaus Centennial Conference (eds Gorfein, D. & Hoffman, R. R.), pp. 349379. Hillsdale, NJ: Lawrence Erlbaum.Google Scholar
Rossor, M. N., Iversen, L. L., Reynolds, G. P., et al (1984) Neurochemical characteristics of early and late onset types of Alzheimer's disease. British Medical Journal, 288, 961964.Google Scholar
Roth, M., Tym, E., Mountjoy, C. Q., et al (1986) CAMDEX: a standardised instrument for the diagnosis of mental disorder in the elderly with special reference to the early detection of dementia. British Journal of Psychiatry, 146, 698709.Google Scholar
Sahgal, A. (1984) A critique of the vasopressin-memory hypothesis. Psychopharmacology, 83, 215228.Google Scholar
Salazar, A. M., Grafman, J., Schlesselman, S., et al (1986) Penetrating war injuries of the basal forebrain: neurology and cognition. Neurology, 36, 459465.Google Scholar
Schacter, D. L. (1987) Implicit memory: history and current status. Journal of Experimental Psychology: Learning, Memory and Cognition, 13, 501518.Google Scholar
Schacter, D. L., Harbluk, J. L. & MClachlan, D. R. (1984) Retrieval without recollection: an experimental analysis of source amnesia. Journal of Verbal Learning and Verbal Behavior, 23, 593611.Google Scholar
Schacter, D. L. & Graf, P. (1986) Preserved learning in amnesic patients: perspectives from research on direct priming. Journal of Clinical and Experimental Neuropsychology, 8, 727743.Google Scholar
Schenker, S., Henderson, G. I., Hoyumpa, A. M., et al (1980) Hepatic and Wernicke's encephalopathies: current concepts of pathogenesis. American Journal of Clinical Nutrition, 33, 27192726.Google Scholar
Serdaru, M., Hausser-Hauw, C., Laplane, D., et al (1988) The clinical spectrum of alcoholic pellagra encephalopathy. Brain, 111, 829842.Google Scholar
Shepherd, G. M. (1988) A basic circuit of cortical organization. In Perspectives in Memory Research (ed. Gazzaniga, M. S.). Cambridge, MA: Massachusetts Institute of Technology Press.Google Scholar
Shimamura, A. P. (1986) Priming effects in amnesia: evidence for a dissociable memory function. Quarterly Journal of Experimental Psychology, 38A, 619644.Google Scholar
Shimamura, A. P. & Squire, L. R. (1984) Paired-associate learning and priming effects in amnesia: a neuropsychological study. Journal of Experimental Psychology, 133, 556570.Google Scholar
Shimamura, A. P. & Squire, L. R. (1986) Korsakoff's syndrome: a study of the relation between anterograde amnesia and remote memory impairment. Behavioral Neuroscience, 100, 165170.Google Scholar
Shimamura, A. P. & Squire, L. R. (1987) A neuropsychological study of fact memory and source amnesia. Journal of Experimental Psychology: Learning, Memory, Cognition, 13, 464473.Google Scholar
Shimamura, A. P., Jernigan, T. L. & Squire, L. R. (1988) Korsakoff's syndrome: radiological (CT) findings and neuropsychological correlates. Journal of Neuroscience, 8, 44004410.Google Scholar
Shimamura, A. P., Janowsky, J. S. & Squire, L. R. (1990) Memory for the temporal order of events in patients with frontal lobe lesions and amnesic patients. Neuropsychologia, 28, 803813.Google Scholar
Shoqeirat, M. A., Mayes, A., MacDonald, C., et al (1990) Performance on tests sensitive to frontal lobe lesions by patients with organic amnesia: Leng and Parkin revisited. British Journal of Clinical Psychology, 29, 401408.Google Scholar
Shoqeirat, M. A. & Mayes, A. (1991) Disproportionate incidental spatial memory and recall deficits in amnesia. Neuropsychologia, 29, 749770.Google Scholar
Snowden, J. S., Goulding, P. J. & Neary, D. (1989) Semantic dementia: a form of circumscribed cerebral atrophy. Behavioural Neurology, 2, 167182.Google Scholar
Speedie, L. J. & Heilman, K. M. (1982) Amnesic disturbance following infarction of the left dorsomedial nucleus of the thalamus. Neuropsychologia, 20, 597604.Google Scholar
Squire, L. R. (1981) Two forms of human amnesia: an analysis of forgetting. Journal of Neuroscience, 1, 635640.Google Scholar
Squire, L. R. (1982) Comparisons between forms of amnesia: some deficits are unique to Korsakoff's syndrome. Journal of Experimental Psychology: Learning, Memory, Cognition, 8, 560572.Google Scholar
Squire, L. R. (1987) Memory and Brain. Oxford: Oxford University Press.Google Scholar
Squire, L. R., Amaral, D. G., Zola-Morgan, S., et al (1989a) Description of brain injury in the amnesic patient N.A. based on magnetic resonance imaging. Experimental Neurology, 105, 2335.Google Scholar
Squire, L. R., Haist, F. & Shimamura, A. P. (1989b) The neurology of memory: quantitative assessment of retrograde amnesia in two types of amnesic patients. Journal of Neuroscience, 9, 828839.Google Scholar
Squire, L. R., Amaral, D. G. & Press, G. A. (1990) Magnetic resonance imaging of the hippocampal formation and mammillary nuclei distinguish medical temporal lobe and diencephalic amnesia. Journal of Neuroscience, 10, 31063117.Google Scholar
Squire, L. R. & Butters, N. (1992) Neuropsychology of Memory (2nd edn). New York: Guilford.Google Scholar
Stuss, D. T., Alexander, M. P., Liberman, A., et al (1978) An extraordinary form of confabulation. Neurology, 28, 11661172.Google Scholar
Tallaksen, C. M. E., Bell, H. & Bohmer, T. (1993) Thiamin and thiamin phosphate ester deficiency assessed by high performance liquid chromatography in four clinical cases of Wernicke encephalopathy. Alcoholism: Clinical and Experimental Research, 17, 712716.Google Scholar
Talland, G. A. (1965) Deranged Memory: A Psychogenic Study of the Amnesic Syndrome. New York: Academic Press.Google Scholar
Torvik, A., Lindboe, C. F. & Rogde, S. (1982) Brain lesions in alcoholics. Journal of Neurological Science, 56, 233248.Google Scholar
Tulving, E. (1972) Episodic and semantic memory. In Organisation of Memory (eds Tulving, E. & Donaldson, W.). London: Academic Press.Google Scholar
Tulving, E. & Thomson, D. M. (1973) Encoding specificity and retrieval processes in episodic memory. Psychological Review, 80, 353373.Google Scholar
Tulving, E. & Schacter, D. L. (1990) Priming and human memory systems. Science, 247, 301306.Google Scholar
Valenstein, E., Bowers, D., Verfaellie, M., et al (1987) Retrosplenial amnesia. Brain, 110, 16311646.Google Scholar
Victor, M. & Adams, R. D. (1953) The effect of alcohol on the nervous system. In Metabolic and Toxic Diseases of the Nervous System. Association for Research in Nervous and Mental Disease, Vol. 32. Baltimore: Williams and Wilkins.Google Scholar
Victor, M., Adams, R. D. & Collins, G. H. (1971) The Wernicke-Korsakoff Syndrome. F. A. Davis.Google Scholar
Victor, M. & Adams, R. D. (1985) The alcoholic dementias. In Handbook of Clinical Neurology, Vol 2 (46) (ed. Fredericks, J. A. M.), pp. 335351. Amsterdam: Elsevier.Google Scholar
Von Cramon, D. Y., Hebel, N. & Schuri, U. (1985) A contribution to the anatomical basis of thalamic amnesia. Brain, 108, 9971008.Google Scholar
Von Cramon, D. Y. & Schuri, U. (1992) The septo-hippocampal pathways and their relevance to human memory: a case report. Cortex, 28, 411422.Google Scholar
Wallis, W. E., Willoughby, E. & Baker, P. (1978) Coma in the Wernicke-Korsakoff syndrome. Lancet, 2, 400401.Google Scholar
Warrington, E. K. (1982) The double deviation of short- and long-term memory deficits. In Human Memory and Amnesia (ed. Cermak, L. S.), pp. 6176. Hillsdale, NJ: Lawrence Erlbaum.Google Scholar
Warrington, E. K. & Weiskrantz, L. (1970) Amnesic syndrome: consolidation or retrieval? Nature, 228, 628630.Google Scholar
Warrington, E. K. & Weiskrantz, L. (1982) Amnesia – a disconnection syndrome? Neuropsychologia, 20, 233248.Google Scholar
Wechsler, D. (1945) A standard memory scale for clinical use. Journal of Psychology, 19, 8795.Google Scholar
Wingartner, H., Rudorfer, M. V., Buchsbaum, M. S., et al (1983a) Effects of serotonin on memory impairments produced by ethanol. Science, 221, 472473.Google Scholar
Wingartner, H., Grafman, J., Boutelle, W., et al (1983b) Forms of memory failure. Science, 221, 380382.Google Scholar
Weiskrantz, L. (1985) On issues and theories of the human amnesic syndrome. In Memory Systems of the Brain (eds Weinberger, N. M., McGaugh, J. L. & Lynch, G.), pp. 380415.Google Scholar
Weiskrantz, L. & Warrington, E. K. (1979) Conditioning in amnesia patients. Neuropsychologia, 17, 187194.Google Scholar
Winocur, G., Oxbury, S., Roberts, R., et al (1984) Amnesia in a patient with bilateral lesions to the thalamus. Neuropsychologia, 22, 123143.Google Scholar
Witt, E. D. (1985) Neuroanatomical consequences of thiamine deficiency: a comparative analysis. Alcohol and Alcoholism, 20, 201221.Google Scholar
Wood, P., Murray, A., Sinha, B., et al (1983) Wernicke's encephalopathy induced by hyperemesis gravidarum case reports. British Journal of Obstetrics and Gynaecology, 90, 583586.Google Scholar
Zangwill, O. L. (1946) Some qualitative observations on verbal memory in cases of cerebral lesion. British Journal of Psychology, 37, 819.Google Scholar
Zangwill, O. L. (1953) Disorientation for age. Journal of Mental Science, 99, 698701.Google Scholar
Zola-Morgan, S., Squire, L. R. & Amaral, D. G. (1986) Human amnesia and the medial temporal region: enduring memory impairment following a bilateral lesion limited to field CA1 of the hippocampus. Journal of Neuroscience, 6, 29502967.Google Scholar
Zola-Morgan, S. & Squire, L. R. (1989a) Lesions of the hippocampal formation but not lesions of the fornix or the mammillary nuclei produce long-lasting memory impairments in monkeys. Journal of Neuroscience, 9, 898913.Google Scholar
Zola-Morgan, S. & Squire, L. R. (1989b) Lesions of the amygdala that spare adjacent cortical regions do not impair memory or exacerbate the impairment following lesions of the hippocampal formation. Journal of Neuroscience, 9, 19221936.Google Scholar
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