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Child and Adolescent (Juvenile Onset) Schizophrenia

A case control study of premorbid developmental impairments

Published online by Cambridge University Press:  02 January 2018

Chris Hollis*
Affiliation:
Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Denmark Hill, London SE5 8AF

Abstract

Background

The study tests the hypothesis that juvenile-onset schizophrenia is associated with premorbid developmental impairments. It was predicted that the pattern of developmental impairments would vary with age of onset and with gender.

Method

A case-control design was used to examine developmental impairments in 61 consecutive juvenile-onset (age 7–17) referrals with ICD-9 schizophrenia; 61 non-psychotic psychiatric controls were matched on age and gender. Cases and controls were divided into childhood-onset (age 7–13) and adolescent-onset (age 14–17).

Results

The schizophrenic cases had a significantly higher risk of premorbid social (χ2 = 9.1, P<0.005), motor (χ2 = 9.1, P<0.005) and language impairments (χ2 = 10.1, P<0.005). Specific impairments of language production and comprehension were associated with childhood-onset schizophrenia and were independent of gender.

Conclusions

Juvenile-onset schizophrenia is associated with a range of developmental antecedents. There may be a specific link between cases with a very early onset and an impairment in the processes underlying the development of language.

Type
Papers
Copyright
Copyright © Royal College of Psychiatrists, 1995 

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References

Ambelas, A. (1992) Preschizophrenics: adding to the evidence, sharpening the focus. British Journal of Psychiatry, 160, 401404.Google Scholar
Asarnow, J. R. & Ben-Meir, S. (1988) Children with schizophrenia spectrum and depressive disorders: A comparative study of premorbid adjustment, onset pattern and severity of impairment. Journal of Child Psychology and Psychiatry, 29, 477488.CrossRefGoogle ScholarPubMed
Erlenmeyer-Kimling, L. (1987) Biological markers for the liability to schizophrenia. In Biological Perspectives of Schizophrenia (eds H. Helmchen & F. A. Henn). pp. 3356. Chichester: John Wiley.Google Scholar
Fish, B., Marcus, J., Hans, S., et al (1992) Infants at risk for schizophrenia: Sequelae of a genetic neurointegrative defect. Archives of General Psychiatry, 49, 221–35.Google Scholar
Foerster, A., Lewis, S., Owen, M., et al (1991) Pre-morbid adjustment and personality in psychosis. The British Journal of Psychiatry, 158, 171176.Google Scholar
Goodman, R. & Simonoff, E. (1991) Reliability of clinical ratings by trainee child psychiatrists. Journal of Child Psychology and Psychiatry, 32, 552557.Google Scholar
Kretschmer, E. (1921) Physique and Character (trans. 1936). London: Kegan Paul.Google Scholar
Norusis, M. J. (1988) SPSS/PC+™ v. 20. Base manual. Chicago: SPSS.Google Scholar
Offord, D. R. & Cross, L. A. (1969) Behavioural antecedents of adult schizophrenia. Archives of General Psychiatry, 21, 267283.Google Scholar
Rapin, I. & Allen, D. (1993) Developmental language disorders: nosological considerations. In Neuropsychology of Language, Reading and Spelling (ed. U. Kirk), pp. 155184. New York: Academic Press.Google Scholar
Thorley, G. (1982) The Bethlem Royal and Maudsley Hospitals' Clinical Data Register for Children and Adolescents. Journal of Adolescence, 5, 179189.CrossRefGoogle ScholarPubMed
Walker, E. & Lewine, R. J. (1990) Prediction of adult-onset schizophrenia from childhood home movies of the patients. American Journal of Psychiatry, 147, 10521056.Google ScholarPubMed
Watkins, J. M., Asarnow, R. F. & Tanguay, P. E. (1988) Symptom development in childhood onset schizophrenia. Journal of Child Psychology and Psychiatry, 29, 865878.CrossRefGoogle ScholarPubMed
Watt, N. S. & Lubensky, A. W. (1976) Childhood roots of schizophrenia. Journal of Consulting and Clinical Psychology, 44, 367375.CrossRefGoogle ScholarPubMed
Zigler, E. & Levine, J. (1973) Pre-morbid adjustment and paranoid–nonparanoid status in schizophrenia: a further investigation. Journal of Abnormal Psychology, 82, 189199.CrossRefGoogle Scholar
Zigler, E., Levine, J. & Zigler, B. (1977) Pre-morbid social competence and paranoid–nonparanoid status in female schizophrenic patients. Journal of Nervous and Mental Disease, 164, 333339.CrossRefGoogle Scholar
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