The British Journal of Psychiatry
Antecedents of schizophrenia and affective illness. Obstetric complications.
A Sacker, D J Done, T J Crow, J Golding


BACKGROUND This exploratory study seeks to generate new hypotheses about the relationship between obstetric complications and schizophrenia.

METHOD The British Perinatal Mortality Survey represents 98% of all births during one week in March 1958 in Great Britain. Present State Examination (PSE), Catego diagnoses of narrowly defined schizophrenia (n = 49), broadly defined schizophrenia (n = 79), affective psychosis (n = 44) and neurosis (n = 93) were derived from case notes for all cohort members. The remainder of the cohort, surviving the perinatal period, acted as controls (n = 16 812). Variables in the British Perinatal Mortality Survey were grouped into five categories: the physique/lifestyle of the mother (including demographic characteristics), her obstetric history, the current pregnancy, the delivery and the condition of the baby.

RESULTS There were 7/17 significant differences in maternal physique/lifestyle and obstetric history between the births of schizophrenics and controls, compared to 4/40 comparisons of somatic variables relating to pregnancy, birth and the condition of the baby. This compares with 4/17 and 7/40 for affective psychotics and a total of 4/57 differences for all categories of variables when neurotics were contrasted with controls.

CONCLUSIONS The purported increased risk of obstetric complications in schizophrenics may result from the physique/lifestyle of their mothers.