BACKGROUND Cyproheptadine, an antiserotonergic agent, was used to treat neuroleptic-induced akathisia.
METHOD In an open clinical trial 17 neuroleptic-treated patients with akathisia were administered cyproheptadine (16 mg/day) over 4 days. Assessment of akathisia, psychosis and depression were monitored by BAS, BPRS and HAM-D.
RESULTS All subjects showed improvement in the severity of akathisia, which in the majority (15/17) was of a marked degree. There was no aggravation of psychosis or depression. Symptoms of akathisia returned when cyproheptadine was discontinued.
CONCLUSIONS Cyproheptadine may be useful in neuroleptic-induced akathisia.