Hostname: page-component-8448b6f56d-qsmjn Total loading time: 0 Render date: 2024-04-23T18:09:31.777Z Has data issue: false hasContentIssue false
  • English
  • Français

The Galway Study of Panic Disorder III

Outcome at 5 to 6 Years

Published online by Cambridge University Press:  02 January 2018

D. O'rourke ,
T. J. Fahy ,
J. Brophy  and
P. Prescott
D. O'rourke
Affiliation:
St Mary's Hospital, Castlebar, Co. Mayo, Ireland
T. J. Fahy*
Affiliation:
Clinical Science Institute, University College Hospital, Galway, Ireland
J. Brophy
Affiliation:
Newcastle Hospital, Wicklow, Ireland
P. Prescott
Affiliation:
Faculty of Mathematical Studies, University of Southampton, Highfield, Southampton, UK
*
Professor T. J. Fahy, Clinical Science Institute, University College Hospital, Galway, Ireland
Get access Rights & Permissions [Opens in a new window]

Abstract

Background

The aim was to evaluate long-term outcome of DSM–III–R panic disorder at a mean of 5.3 years following a controlled trial of treatment that included antidepressants and behavioural counselling.

Method

Sixty-eight (86%) subjects were evaluated by lengthy research interview.

Results

Thirty-four per cent recovered and remained well, 46% were minimally impaired and 20% had persistent panic disorder of whom half remained significantly impaired. Anxious–fearful personality dysfunction was the most important predictor of poor outcome, followed by poor clinical status at discharge and inability at baseline to recall vividly the initial panic attack. Those who dropped out from the original trial did badly.

Conclusions

Complete recovery can occur even after many years of severe illness in a large minority of subjects who receive both antidepressants and behavioural counselling in the acute stage of treatment. The comparative prognostic value of personality, severity and chronicity need to be more fully addressed in future studies.

Type
Papers
Information
The British Journal of Psychiatry , Volume 168 , Issue 4 , April 1996 , pp. 462 - 469
Copyright
Copyright © Royal College of Psychiatrists, 1996 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

American Psychiatric Association (1987) Diagnostic and Statistical Manual of Mental Disorders (3rd edn, revised) (DSM–III–R). Washington, DC: APA.Google Scholar
Cloninger, C. R. & Svrakic, D. M. (1992) Personality dimensions as a conceptual framework for explaining variations in normal, neurotic, and personality disordered behaviour. In Handbook of Anxiety, Vol. 5 (eds Burrows, G. D., Roth, M. & Noyes, R. Jr), pp. 79–104. Amsterdam: Elsevier.Google Scholar
Di Nardo, P. A., Moras, K., Barlow, D. H., et al (1993) Reliability of DSM–III–R anxiety disorder categories using the Anxiety Disorders Interview Schedule–Revised (ADIS–R). Archives of General Psychiatry, 50, 251–256.Google Scholar
Fahy, T. J., O'rourke, D., Brophy, J., et al (1992) The Galway study of panic disorder I: Clomipramine and lofepramine in DSM–III–R Panic Disorder: A placebo controlled trial. Journal of Affective Disorder, 25, 63–76.CrossRefGoogle ScholarPubMed
Fava, G. A., Zielezny, M., Savron, G., et al (1995) Long-term effects of behavioural treatment for panic disorder with agoraphobia. British Journal of Psychiatry, 166, 87–92.CrossRefGoogle ScholarPubMed
Hirschfeld, R. M. A. (1992) The clinical course of panic disorder and agoraphobia. In Handbook of Anxiety, Vol. 5 (eds Burrows, G. D., Roth, M. & Noyes, R. Jr), pp. 105–119. Amsterdam: Elsevier.Google Scholar
Lelliott, P. T., Marks, I. M., McNamee, G., et al (1989) Onset of panic disorder with agoraphobia: Towards an integrated model. Archives of General Psychiatry, 46, 1000–1004.CrossRefGoogle Scholar
Lewis, G. & Appleby, L. (1988) Personality disorder: the patients psychiatrists dislike. British Journal of Psychiatry, 153, 44–49.Google Scholar
Marks, I. M. & Swinson, R. P. (1992) Behavioural and/or drug therapy. In Handbook of Anxiety, Vol. 5 (eds Burrows, G. D., Roth, M. & Noyes, R. Jr), pp. 255–268. Amsterdam: Elsevier.Google Scholar
Mavissakalian, M., Michelson, L. & Dealy, R. S. (1983) Pharmacological treatment of agoraphobia: Imipramine versus Imipramine with programmed practice. British Journal of Psychiatry, 143, 348–355.Google Scholar
Noyes, R. Jr. (1992) The outcome of panic disorder as influenced by illness variables and coexisting syndromes. In Handbook of Anxiety, Vol. 5 (eds Burrows, G. D., Roth, M. & Noyes, R. Jr), pp. 137–160. Amsterdam: Elsevier.Google Scholar
O'Sullivan, G. & Marks, I. M. (1990) Long-term outcome of phobic and obsessive–compulsive disorders after treatment. In Handbook of Anxiety, Vol. 4 (eds Noyes, R., Burrows, G. D. & Roth, M.), pp. 87–108. Amsterdam: Elsevier.Google Scholar
Roth, M. (1992) Concept of general neurotic syndrome. In Handbook of Anxiety, Vol. 5 (eds Burrows, G. D., Roth, M. & Noyes, R. Jr), pp. 1–19. Amsterdam: Elsevier.Google Scholar
Shear, M. K. & Maser, J. D. (1994) Standardized assessment for panic disorder research: a conference report. Archives of General Psychiatry, 51, 346–354.Google Scholar
Taylor, S. & Livesley, W. J. (1995) The influence of personality on the clinical course of neurosis. Current Opinion in Psychiatry, 8, 93–97.CrossRefGoogle Scholar
Telch, M. J., Agras, W. S., Taylor, C. B., et al (1985) Combined pharmacological and behavioural treatment for agoraphobia. Behaviour Research and Therapy, 23, 325–335.Google Scholar
Wolpe, J. & Lange, P. J. (1972) A fear survey schedule for use in behaviour therapy. Behaviour Research and Therapy, 2, 27–30.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.