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A Genetic Linkage Study of the D2 Dopamine Receptor Locus in Heavy Drinking and Alcoholism

Published online by Cambridge University Press:  02 January 2018

C. C. H. Cook ,
G. Palsson ,
A. Turner ,
D. Holmes ,
P. Brett ,
D. Curtis ,
H. Petursson  and
H. M. D. Gurling
C. C. H. Cook*
Affiliation:
National Addiction Centre, London
G. Palsson
Affiliation:
Skogveien 9a, Sortland, Norway
A. Turner
Affiliation:
Molecular Psychiatry Laboratory, University College London Medical School, London
D. Holmes
Affiliation:
Worcester College of Higher Education, Worcester
P. Brett
Affiliation:
St Thomas' Hospital, London
D. Curtis
Affiliation:
Joint Academic Department of Psychiatry, St Bartholomew's and the Royal London School of Medicine and Dentistry, London
H. Petursson
Affiliation:
Department of Psychiatry, Borgarspitalinn/University of Iceland
H. M. D. Gurling
Affiliation:
Molecular Psychiatry Laboratory, University College London Medical School, London
*
Dr C. Cook, Consultant and Senior Lecturer in the Addictions, National Addiction Centre, 4 Windsor Walk, London SE5 8AF
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Abstract

Background

Reports of an association between restriction fragment length polymorphisms (RFLPs) at the dopamine D2 receptor (DRD2) locus and alcoholism have suggested involvement of that locus in the aetiology of alcoholism.

Method

Sib pair linkage analyses were conducted in families multiply affected by alcoholism, using both the Taql ‘A’ RFLP and a microsatellite repeat polymorphism at the DRD2 locus.

Results

The ‘Identical By Descent’ analysis provided significant evidence of an effect of the DRD2 locus on the liability to develop heavy drinking (P<0.0016) and Research Diagnostic Criteria alcoholism (P<0.0003) in the first sample of families studied. However, this result was explicable by the segregation of alleles in a single large sibship, and it was not replicated in a second sample of families.

Conclusions

The results do not support linkage between the DRD2 locus and alcoholism in most of the families studied. It remains possible that this locus influences the predisposition to alcoholism in some families.

Type
Papers
Information
The British Journal of Psychiatry , Volume 169 , Issue 2 , August 1996 , pp. 243 - 248
Copyright
Copyright © 1996 The Royal College of Psychiatrists 

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