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Psychiatric Genetics

Published online by Cambridge University Press:  02 January 2018

Nick Craddock*
Affiliation:
Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN. E-mail: craddock@cardiff.ac.uk

Abstract

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Columns
Copyright
Copyright © 1996 The Royal College of Psychiatrists 

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References

Anonymous (1996) A glossary of molecular genetics. Drugs and Therapeutics Bulletin, 34, 1516.Google Scholar
Baron, M., Risch, N., Hamburger, R., et al (1987) Genetic linkage between X-chromosome markers and bipolar affective illness. Nature, 326, 289292.Google Scholar
Baron, M., Freimer, N. F., Risch, N., et al (1993) Diminished support for linkage between manic-depressive illness and X-chromosome markers in three Israeli pedigrees. Nature Genetics, 3, 4955.Google Scholar
Bassett, A. S. (1992) Chromosomal aberrations and schizophrenia. British Journal of Psychiatry, 161, 323334.Google Scholar
Bassett, A. S. & Honer, W. G. (1994) Evidence for anticipation in schizophrenia. American Journal of Human Genetics, 54, 864870.Google ScholarPubMed
Berrettini, W. H., Ferraro, T. N., Goldin, , et al (1994) Chromosome 18 DNA markers and manic-depressive illness: evidence for a susceptibility gene. Proceedings of the National Academy of Sciences of the United States of America, 91, 59185921.Google Scholar
Blackwood, D. H. R., He, L., Morris, S. W., et al (1996) A locus for bipolar affective disorder on chromosome 4p. Nature Genetics, 12, 427430.Google Scholar
Bodmer, W. & McKie, R. (1995) The Book of Man. The Quest to Discover Our Genetic Heritage. London: Abacus.Google Scholar
Bouchard, T. J., Lykken, D. T., McGue, M., et al (1990) Sources of human psychological differences: the Minnesota study of twins reared apart. Science, 250, 223228.Google Scholar
Cooper, D. N. & Clayton, J. F. (1988) DNA polymorphism and the study of disease associations. Human Genetics, 78, 299312.Google Scholar
Corder, E. H., Saunders, A. M., Strittmatter, W. J., et al (1993) Gene dose of Apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science, 261, 921923.CrossRefGoogle ScholarPubMed
Craddock, N., Khodel, V., Van Eerdewegh, P., et al (1995) Mathematical limits of multi-locus models: the genetic transmission of bipolar disorder. American Journal of Human Genetics, 57, 690702.Google Scholar
Craddock, N. & Owen, M. (1994) Chromosomal aberrations and bipolar affective disorder. British Journal of Psychiatry, 164, 507512.CrossRefGoogle ScholarPubMed
Craddock, N. & Owen, M. (1996) Modern molecular genetic approaches to psychiatric disease. British Medical Bulletin, 52, 434452.Google Scholar
Dawson, E., Parfitt, E., Roberts, Q., et al (1995) Linkage studies of bipolar disorder in the region of the Darier's disease gene on chromosome 12q23–24.1. American Journal of Medical Genetics (Neuropsychiatric Genetics), 60, 94102.CrossRefGoogle ScholarPubMed
Egeland, J. A., Gerhard, D. S., Pauls, D. L., et al (1987) Bipolar affective disorders linked to DNA markers on chromosome 11. Nature, 325, 783787.Google Scholar
Farmer, A. & Owen, M. J. (1996) Genomics: the next psychiatric revolution? British Journal of Psychiatry, 169, 135138.Google Scholar
Falconer, D. S. (1989) Introduction of Quantitative Genetics. New York: John Wiley.Google Scholar
Freimer, N. B., Reus, V. I., Escamilla, M. A., et al (1996) Genetic mapping using haplotype, association and linkage methods suggests a locus for severe bipolar disorder (BPI) at 18q22–123. Nature Genetics, 12, 436441.Google Scholar
Goate, A., Chartier-Harlin, M.-C., Mullan, M., et al (1991) Segregation of a missense mutation in the amyloid precursor protein gene with familiar Alzheimer's disease. Nature, 349, 704707.Google Scholar
Gottesman, I. I. (1991) Schizophrenia Genesis. The Origins of Madness. New York: W.H. Freeman.Google Scholar
Inayama, Y., Yoneda, H., Sakai, T., et al (1996) Positive association between a DNA sequence variant in the serotonin 2A receptor gene and schizophrenia. American Journal of Medical Genetics (Neuropsychiatric Genetics), 67, 103105.Google Scholar
Jordan, E. & Collins, F. S. (1996) A march of genetic maps. Nature, 380, 111112.Google Scholar
Kelsoe, J. R., Ginns, E. I., Egeland, J. A., et al (1989) Re-evaluation of the linkage relationship between chromosome 11p loci and the gene for bipolar affective disorder in the Old Order Amish. Nature, 342, 238243.Google Scholar
Kendler, K. S., Neale, M. C., Kessler, R. C., et al (1992) Major depression and generalized anxiety disorder. Same genes, (partly) different environments. Archives of General Psychiatry, 49, 716722.CrossRefGoogle ScholarPubMed
Kendler, K. S., McGuire, M., Gruenberg, A. M., et al (1993) The Roscommon family study. I. Methods, diagnosis of probands, and risk of schizophrenia in relatives. Archives of General Psychiatry, 50, 527540.CrossRefGoogle Scholar
Kendler, K. S., Walers, E. E., Neale, M. C., et al (1995) The structure of the genetic and environmental risk factors for six major psychiatric disorders in women. Phobia, generalized anxiety disorder, panic disorder, bulimia, major depression and alcoholism. Archives of General Psychiatry, 52, 374383.Google Scholar
Khoury, M. J., Beaty, T. H. & Cohen, B. H. (1993) Fundamentals of Genetic Epidemiology. Oxford: Oxford University Press.Google Scholar
Lander, E. S. & Schork, N. J. (1994) Genetic dissection of complex traits. Science, 265, 20372048.Google Scholar
Lander, E. S. & Kruglyak, L. (1995) Genetic dissection of complex traits: guidelines for interpreting reporting linkage results. Nature Genetics, 11, 241247.Google Scholar
Lin, M. W., Curtis, D., Williams, N., et al (1995) Suggestive evidence for linkage of schizophrenia to markers on chromosome 13q14.1-q32. Psychiatric Genetics, 5, 117126.CrossRefGoogle ScholarPubMed
Lindblad, K., Nylander, P.-O., De Bruyn, A., et al (1995) Detection of expanded CAG repeats in Bipolar Affective Disorder using the repeat expansion detection (RED) method. Neurobiology of Disease, 2, 5562.Google Scholar
Maier, W., Lichtermann, D., Minges, J., et al (1993) Continuity and discontinuity of affective disorders and schizophrenia. Results of a controlled family study. Archives of General Psychiatry, 50, 871883.Google Scholar
Mankoo, B., Sherrington, R., Brynjolfsson, J., et al (1991) New microsatellite polymorphisms provide a highly polymorphic map of chromosome 5 bands q11.2-q13.3 for linkage analysis of Icelandic and British families affected by schizophrenia. Psychiatric Genetics, 2, 17 (abstract).Google Scholar
McGue, M. & Gottesman, I. I. (1989) Genetic linkage in schizophrenia: perspectives from genetic epidemiology. Schizophrenia Bulletin, 15, 453464.Google Scholar
McGuffin, P., Owen, M. J., O'Donovan, M. C., et al (1994) Seminars in Psychiatric Genetics. London: Gaskell.Google Scholar
McGuffin, P., Katz, R., Watkins, S., et al (1996) A hospital-based twin register of the heritability of DSM-IV unipolar depression. Archives of General Psychiatry, 53, 129136.Google Scholar
McInnis, M. G., McMahon, F. J., Chase, G. A., et al (1993) Anticipation in bipolar affective disorder. American Journal of Human Genetics, 53, 385390.Google Scholar
Moises, H. W., Yang, L., Kristbjarnarson, H., et al (1995) An international two-stage genome-wide search for schizophrenia susceptibility genes. Nature Genetics, 11, 321324.Google Scholar
Morris, A. G., Gaitonde, E., McKenna, P. J., et al (1995) CAG repeat expansions and schizophrenia: association with disease in females and with early age-at-onset. Human Molecular Genetics, 4, 19571961.Google Scholar
Mott, F. W. (1910) Hereditary aspects of nervous and mental diseases. British Medical Journal, ii, 10131020.Google Scholar
Murphy, K. C. & Owen, M. J. (1996) Schizophrenia, CATCH 22 and FISH. British Journal of Psychiatry, 168, 397398.Google Scholar
Neale, M. C. & Cardon, L. R. (1992) Methodology for Genetic Studies in Twins and Families. New York: Kluwer Academic.Google Scholar
Nicholl, D. S. T. (1994) An Introduction to Genetic Engineering. Cambridge: Cambridge University Press.Google Scholar
O'Donovan, M. C., Guy, C., Craddock, N., et al (1995) Expanded CAG repeats in schizophrenia and bipolar disorder. Nature Genetics, 10, 380381.Google Scholar
O'Donovan, M. C., Guy, C., Craddock, N., et al (1996) Confirmation of association between expanded CAG/CTG repeats and both schizophrenia and bipolar disorder. Psychological Medicine, in press.Google Scholar
O'Donovan, M. C., & Owen, M. J. (1996) Dynamic mutations and psychiatric genetics. Psychological Medicine, 26, 16.Google Scholar
Ott, J. (1991) Analysis of Human Genetic Linkage (revised edition). Baltimore: The Johns Hopkins University Press.Google Scholar
Owen, M. & McGuffin, P. (1992) The molecular genetics of schizophrenia. British Medical Journal, 305, 664665.Google Scholar
Pekkarinen, P.J.T., Bredbacka, P.-E., Loonqvist, J., et al (1995) Evidence of a predisposing locus to bipolar disorder on Xq24-q27. One in an extended Finnish pedigree. Genome Research, 5, 105115.Google Scholar
Plomin, R. (1990) The role of inheritance in behavior. Science, 248, 183188.Google Scholar
Plomin, R., DeFries, J. C. & McClearn, G. E. (1990) Behavioral Genetics. A Primer. New York: W. H. Freeman and Company.Google Scholar
Plomin, R., Owen, M.J. & McGuffin, P. (1994) The genetic basis of complex human behaviours. Science, 264, 17331739.Google Scholar
Pulver, A. E., Lassester, V. K., Kasch, L., et al (1995) Schizophrenia: a genome scan targets chromosomes 3p and 8p as potential sites of susceptibility genes. American Journal of Medical Genetics (Neuropsychiatric Genetics), 60, 252260.Google Scholar
Risch, N. (1990) Linkage strategies for genetically complex traits. I. Multilocus models. American Journal of Human Genetics, 46, 222228.Google ScholarPubMed
Rogaev, E. I., Sherrington, R., Rogaeva, E. A., et al (1995) Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene. Nature, 376, 775779.Google Scholar
Sandbrink, R., Hartmann, T., Masters, C. L., et al (1996) Genes contributing to Alzheimer's disease. Molecular Psychiatry, 1, 2740.Google Scholar
Schaid, D. J. & Sommer, S. S. (1994) Comparison of statistics for candidate-gene association studies using cases and parents. American Journal of Human Genetics, 55, 402409.Google Scholar
Schizophrenia Collaborative Linkage Group (Chromosome 22) (1996) A combined analysis of D22S278 marker alleles in affected sib-pairs: support for a susceptibility locus for schizophrenia at chromosome 22q12. American Journal of Medical Genetics (Neuropsychiatric Genetics), 67, 4045.Google Scholar
Schwab, S. G., Albus, M., Hallmayer, J., et al (1995) Evaluation of a susceptibility gene for schizophrenia on chromosome 6p by multipoint affected sib-pair linkage analysis. Nature Genetics, 11, 325327.Google Scholar
Sham, P. (1996) Genetic epidemiology. British Medical Bulletin, 52, 408433.CrossRefGoogle ScholarPubMed
Sham, P., Jones, P. A. R., Gilvarry, K., et al (1994) Age at onset, sex, and familial psychiatric morbidity in schizophrenia. Camberwell Collaborative Psychosis Study. British Journal of Psychiatry, 165, 466473.Google Scholar
Sherrington, R., Brynjolfsson, J., Petursson, H., et al (1988) Localization of a susceptibility locus for schizophrenia on chromosome 5. Nature, 336, 164167.Google Scholar
Sherrington, R., Rogaev, E. I., Liang, Y., et al (1995) Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature, 375, 754767.Google Scholar
Sobell, J. L., Heston, L. L. & Sommer, S. S. (1992) Delineation of genetic predisposition to multifactorial disease: a general approach on the threshold of feasibility. Genomics, 12, 16.Google Scholar
Stine, O. C., Xu, J., Koskela, R., et al (1995) Evidence for linkage of bipolar disorder to chromosome 18 with a parent-of-origin effect. American Journal of Human Genetics, 57, 13841394.Google ScholarPubMed
Strachan, T. (1992) The Human Genome. Oxford: Bios Scientific Publishers.Google Scholar
Sherrington, R., & Read, A. P. (1996) Human Molecular Genetics. New York: John Wiley & Sons.Google Scholar
Straub, R. E., Lehner, T., Luo, Y., et al (1994) A possible vulnerability locus for bipolar affective disorder on chromosome 21q22.3. Nature Genetics, 8, 291296.Google Scholar
Straub, R. E., MacLean, C. J., O'Neill, F. A., et al (1995) A potential vulnerability locus for schizophrenia on chromosome 6p24–22: evidence for genetic heterogeneity. Nature Genetics, 11, 287293.Google Scholar
Tsuang, M. T. & Faraone, S. V. (1990) The Genetics of Mood Disorders. Baltimore: The Johns Hopkins University Press.Google Scholar
Watson, J. D. (1990) The Human Genome Project: past, present, and future. Science, 248, 4449.Google Scholar
Watson, J. D., Gilman, M., Witowski, J., et al (1992) Recombinant DNA (Second ed.). New York: Scientific American Books.Google Scholar
Williams, J., Spurlock, G., McGuffin, P., et al (1996) Association between schizophrenia and T102C polymorphism of the 5-hydroxytryptamine type 2a-receptor gene. Lancet, 347, 12941296.CrossRefGoogle ScholarPubMed
Wragg, M., Hutton, M., Talbot, C., et al (1996) Genetic association between intronic polymorphism in presenilin-1 gene and late-onset Alzheimer's disease. Lancet, 347, 509512.Google Scholar
Yates, J. R. W. & Connor, J. M. (1986) Genetic linkage. British Journal of Hospital Medicine, 36, 133136.Google Scholar
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