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Cytogenetic abnormalities on chromosome 18 associated with bipolar affective disorder or schizophrenia

Published online by Cambridge University Press:  03 January 2018

Ole Mors ,
Henrik Ewald ,
Douglas Blackwood  and
Walter Muir
Ole Mors*
Affiliation:
Institute for Basic Psychiatric Research, Risskov, Denmark
Henrik Ewald
Affiliation:
Institute for Basic Psychiatric Research, Risskov, Denmark
Douglas Blackwood
Affiliation:
Edinburgh University Department of Psychiatry, and MRC Human Genetics Unit, The Royal Edinburgh, Morningside Park, Edinburgh EH10 5HF
Walter Muir
Affiliation:
Edinburgh University Department of Psychiatry, and MRC Human Genetics Unit, The Royal Edinburgh, Morningside Park, Edinburgh EH10 5HF
*
Dr Ole Mors, Institute for Basic Psychiatric Research, Department of Psychiatric Demography, Skovagervej 2, DK-8240 Risskov, Denmark. Fax: +86 177455
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Abstract

Background

A few recent linkage studies have shown a possible locus for bipolar disorder on chromosome 18. Cytogenetic studies may assist in the further localisation of susceptibility loci on this chromosome.

Method

A search was made for abnormalities of chromosome 18 in two separate large cytogenetic databases. In Denmark detection of mental illness in subjects with chromosome abnormalities was done by cross-linking the two separate register of psychiatric and chromosome disorders. In Scotland the Cytogenetic Registry of the MRC Human Genetics Unit undertakes long-term clinical follow-up of all cases with chromosome abnormalities.

Results

Cross-linking the two Danish register's revealed a family with the rare karyotype abnormality inv(18) (p11.3;q21.1) with one inversion carrier who also suffered from bipolar disorder. In this family there were two other cases of bipolar disorder, but the karyotype of these cases could not be established. One family in Scotland showed a case of schizophrenia in a carrier of inv(18) with the same breakpoints as the Danish family.

Conclusions

We suggest further studies of the 18p11.3 and 18q21.1 regions in order to identify genes involved in bipolar affective disorder and schizophrenia.

Type
Papers
Information
The British Journal of Psychiatry , Volume 170 , Issue 3 , March 1997 , pp. 278 - 280
Copyright
Copyright © 1997 The Royal College of Psychiatrists 

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