Hostname: page-component-8448b6f56d-gtxcr Total loading time: 0 Render date: 2024-04-20T11:14:12.868Z Has data issue: false hasContentIssue false
  • English
  • Français

EEG coherence and syndromes in schizophrenia

Published online by Cambridge University Press:  03 January 2018

R. M. G. Norman ,
A. K. Malla ,
P. C. Williamson ,
S. L. Morrison-Stewart ,
E. Helmes  and
L. Cortese
R. M. G. Norman*
Affiliation:
London Health Sciences Centre, and University of Western Ontario, London, Ontario
A. K. Malla
Affiliation:
London Health Sciences Centre, and University of Western Ontario, London, Ontario
P. C. Williamson
Affiliation:
London Health Sciences Centre, and University of Western Ontario, London, Ontario
S. L. Morrison-Stewart
Affiliation:
North Bay Psychiatry Hospital, North Bay, Ontario
E. Helmes
Affiliation:
Edith Cowan University, Perth, Australia
L. Cortese
Affiliation:
FRCR London Health Sciences Centre, and University of Western Ontario, London, Ontario, Canada
*
Dr R. M. G. Norman, Department of Psychiatry, WMCH, London Health Sciences Centre-Victoria Campus, 392 South Street, London, Ontario N6A 4G5, Canada
Get access Rights & Permissions [Opens in a new window]

Abstract

Background

Frith et al (1995) and others have hypothesised that disruptions in the connection between left frontal and temporal areas of the brain are a central deficit in schizophrenia. In this paper we examine whether such connectivity as assessed by EEG coherence is related to level of symptoms in patients with schizophrenia.

Method

For 73 patients with schizophrenia, assessments of the EEG coherence between frontal and temporal regions were carried out under conditions of activation by a mathematical task, and between frontal and occipital regions when performing a visuo-spatial task. We then examined the relationship between these coherence measures and the reality distortion, disorganisation and psychomotor poverty dimensions of symptomatology.

Results

Only left frontal -temporal connectivity was found to have a significant negative relationship to symptomatology. This relationship was, however, specific to reality distortion rather than to symptoms of disorganisation or psychomotor poverty, and may be more characteristic of males than females.

Conclusions

Disruption of frontaltemporal connectivity appears to have a specific relationship to reality distortion symptoms in schizophrenia.

Type
Papers
Information
The British Journal of Psychiatry , Volume 170 , Issue 5 , May 1997 , pp. 411 - 415
Copyright
Copyright © 1997 The Royal College of Psychiatrists 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Andreasen, N. C. (1983) The Scale for Assessment of Negative Symptoms (SANS). Iowa City: University of Iowa.Google Scholar
Andreasen, N. C. (1984) The Scale fix Assessment of Positive Symptoms (SAPS). Iowa City: University of Iowa.Google Scholar
Castle, D. J. & Murray, R. M. (1991) The neurodevelopmental bases of sex differences in schizophrenia. Psychological Medicine, 21, 565–575.Google Scholar
Cooley, J. & Tukey, J. (1965) An algorithm for the machine calculation of complex Fourier series. Mathematics of Computation, 19, 297–301.Google Scholar
Flor-Henry, P. (1990) Influence of gender in schizophrenia as related to other psychopathological syndromes. Schizophrenia Bulletin. 16, 211–227.Google Scholar
Flor-Henry, P., Fromm-Auch, D. & Schopflocher, D. (1905) Neuropsychological dimensions in psychopathology, in Laterality and Psychopathology (eds P. Flor-Henry & J. Gruzelier), pp. 59–82. North Holland: Elsevier Science.Google Scholar
Friston, K. J., Frith, C. D. L. Liddie, F. F., et al (1993) Frontal connectivity: the principal component analysis of large (PET) data sets, journal of Cerebral Blood Flow and Metabolism, 15, 5–14.Google Scholar
Frith, C.D. (1992) The Cognitive Neuropsychology of Schizophrenia. Hove, Sussex: Lawrence Eribaum.Google Scholar
Frith, C.D., Friston, K.J., Swbersweig, D., et al (1995) Regional brain activity in chronic schizophrenic patients during the performance of a verbal fluency task. British journal of Psychiatry, 167, 343–349.Google Scholar
Gur, R. E., Jaggi, J. L., Shtasel, D. L., et al (1994) Cerebral blood blow in schizophrenia: Effects of memory processing on regional activation. Biological Psychiatry 35, 3–15.CrossRefGoogle Scholar
Kimura, D. (1992) Sex differences in the brain. Scientific American, Sept., 119–125.CrossRefGoogle Scholar
Levine, R. R. J., Gulley, L. R., Risch, S. C., et al (1990) Sexual dimorphism, brain morphology, and schizophrenia. Schizophrenia Bulletin. 16, 195–203.Google Scholar
Lezak, M. (1983) Neuropsychological Assessment. New York: Oxford University Press.Google Scholar
Liddle, P. F. (1987) The symptoms of chronic schizophrenia: a re-examination of the positive-negative dichotomy. British Journal of Psychiatry, 151, 145–151.Google Scholar
Liddle, P. F., Friston, K. J., Frith, C. D., et al (1992) Patterns of cerebral blood flow in schizophrenia. British journal of Psychiotry, 160, 179–186.CrossRefGoogle ScholarPubMed
Malla, A. K., Norman, R. M. C., Williamson, P., et al (1993) Three syndrome concept of schizophrenia: a factor analytic study. Schizophrenia Research, 10, 143–150.Google Scholar
McGlona, J. (1980) Sex differences in human brain asymmetry: A critical survey. Brain and Behavioral Science, 3, 215–263.CrossRefGoogle Scholar
Meng, X.-L., Rosonthal, R. & Rubin, D. B. (1992) Comparing correlated correlation coefficients. Psychological Bulletin. III, 172–175.Google Scholar
Morrison-Stewart, S. L., Willamson, P. C., Coming, W C., et al (1991) Coherence on electroencephalography and aberrant functional organisation of the brain in schizophrenic patients during activation tasks. British journal of Psychiatry. 159, 636–644.CrossRefGoogle ScholarPubMed
Morrison-Stewart, S. L., Willamson, P. C., Coming, W C., Velilconja, D., Corning, W. C., al of (1996) Aberrant interhemispheric alpha coherence on electroencephalography in schizophrenic patients during activation tasks. Psychological Medicine. 26, 605–612.Google Scholar
Norman, R. M.G., Malla, A. K., Morrison-Stewart, S. L., et al (1997) Neuropsychological correlates of syndromes in schizophrenia. British journal of Psychiatry, 170, 134–139.Google Scholar
Raine, A. (1992) Sex differences in schizotypal personality in a non-clinical population, journal of Abnormal Psychology 101, 361–364.Google Scholar
Sharborough, F., Chatrian, G., Low, R., et al (1990) Guidelines for Standard Electrode Position Nomenclature. Bloomfield, CT: American Electroencephalographic Society Google Scholar
Spitzer, R. L. & Wtlliams, J. S. W. (1905) Structured Clinical Interview for DSM-lll-R-Patient Version. New York: New York State Psychiatric Institute, Biometrics Research Department.Google Scholar
Springer, S. & Deutsch, G. (1981) Left Brain. Right Brain. San Francisco, CA: W H. Freeman.Google Scholar
Weinberger, D. R. (1991) Anteriormedial temporal-prefrontal connectivity: A functional anatomical system implicated in schizophrenia. In Psychopathology and the Brain (eds B. J. Carrol & J. E. Barnett), pp. 25–42. New York: Raven Press.Google Scholar
Weinberger, D. R. & Lipska, B. K. (1995) Cortical maldevelopment, antipsychotic drugs, and schizophrenia: a search for common ground. Schizophrenico Research. 16, 87–110.Google Scholar
Wonderlic, C. (1983) Wonderlic Personnel Test. Northfield: E. F.Wonderlic Personnel Test Inc.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.