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Altered dopaminergic function and negative symptoms in drug-free patients with schizophrenia

[123l]-iodobenzamide SPECT study

Published online by Cambridge University Press:  02 January 2018

Michael B. Knable*
Affiliation:
Clinical Disorder Branch, Intramural Research Program, National Institute of Mental Health
Michael F. Egan
Affiliation:
Clinical Disorder Branch, Intramural Research Program, National Institute of Mental Health
Andreas Heinz
Affiliation:
Clinical Disorder Branch, Intramural Research Program, National Institute of Mental Health
Julia Gorey
Affiliation:
Clinical Disorder Branch, Intramural Research Program, National Institute of Mental Health
Kan Sam Lee
Affiliation:
Clinical Disorder Branch, Intramural Research Program, National Institute of Mental Health
Richard Coppola
Affiliation:
Clinical Disorder Branch, Intramural Research Program, National Institute of Mental Health
Daniel R. Weinberger
Affiliation:
Clinical Disorder Branch, Intramural Research Program, National Institute of Mental Health
*
M. B. Knable, Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, 2700 Martin Luther King Jr Ave., S. E., Washington, DC 20032; Fax: 202-373-6214

Abstract

Background

Previous in vivo studies of schizophrenia with dopamine D2 receptor radioligands have yielded contradictory results. No prior study has used multiple scans to examine within-subject clinical change.

Method

Twenty-one patients were studied with [1231]-iodobenzamide single photon emission computed tomography about two weeks after neuroleptic withdrawal. Thirteen of the 21 completed a second scan about four weeks after neuroleptic withdrawal. Sixteen controls were scanned for comparison.

Results

There was no significant difference between groups in [1231]-iodobenzamide uptake at either scanning session. No significant correlations with demographic variables (age, illness duration, drug-free period), or clinical ratings (positive and negative symptoms, movement disorder) were observed at either scanning session. There was a significant correlation between change in [1231]-iodobenzamide uptake and change in negative symptom ratings for the subjects who underwent two scans (r=0.72, P < 0.05)

Conclusions

Worsening of negative symptoms may be associated with increased availability of striatal D2 receptors, perhaps because of decreased concentrations of endogenous dopamine.

Type
Papers
Copyright
Copyright © 1997 The Royal College of Psychiatrists 

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