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Neuroimaging in autism

Published online by Cambridge University Press:  03 January 2018

Shoumitro Deb*
Affiliation:
Department of Psychological Medicine, University of Wales College of Medicine, Cardiff
Bill Thompson
Affiliation:
Department of Psychological Medicine, University of Wales College of Medicine, Cardiff
*
Dr S. Deb, Department of Psychological Medicine. University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN. E-mail: deb@cardiff.ac.uk

Abstract

Background

Childhood autism is a developmental disorder with distinctive clinical features and characteristic cognitive deficits. Neuroimaging techniques have been extensively used in the study of autism and related disorders.

Method

Recent important literature reported on structural and functional neuroimaging in autism was reviewed and discussed in the context of other neurobiological research findings.

Results

Various abnormalities of brain structure and function have been proposed, but no focal defect has been reliably demonstrated. Important findings, so far, include increased brain volume, structural abnormality in frontal lobe and corpus callosum in a proportion of autistic individuals. Functional neuroimaging findings emphasised the imbalance in interregional and inter-hemispheric brain metabolism and blood flow as well as abnormality in the anterior cingulate gyrus.

Conclusion

The research to date has been hindered by methodological difficulties. However, hypothesis-driven research, particularly involving activation studies and neurotransmitter/neuroreceptor activities, using functional neuroimaging will be very useful in unravelling the enigma associated with this intriguing and distressing condition.

Type
Review Article
Copyright
Copyright © 1998 The Royal College of Psychiatrists 

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References

Anderson, G. M., Horne, W. C., Chatterjee, D., et al (1990) The hyperserotonemia of autism. Annals of New York Academy of Science, 600, 331340.Google Scholar
Bailey, A., Le Coutuer, A., Gottesman, I., et al (1995) Autism as a strongly genetic disorder: evidence from a British twin study. Psychological Mediane, 25, 6378.Google Scholar
Baron-Cohen, S., Ring, H., Moriarty, J., et al (1994) Recognition of mental state terms. Clinical findings in children with autism, and a functional neuroimaging study of normal adults. British Journal of Psychiatry, 165, 640649.Google Scholar
Buchsbaum, M. S., Siegel, B. V., Wu, J. C., et al (1992) Brief report: attention performance in autism and regional brain metabolic rate assessed by positron emission tomography. Journal of Autism and Developmental Disorder, 22, 115125.Google Scholar
Chugani, D. C., Muzlk, O., Rothermel, R., et al (1997) Altered serotonin synthesis in the dentato-thalamo-cortical pathway in autistic boys. Annals of Neurology, 42, 666669.Google Scholar
Courchesne, E., Hesselink, J. R., Jernigan, T. L., et al (1987) Abnormal neuroanatomy in a nonretarded person with autism. Archives of Neurology, 44, 335341.Google Scholar
Courchesne, E., Yeung-Courchesne, R., Press, G. A., et al (1988) Hypoplasia of cerebellar vermal lobules VI and VII in autism. New England Journal of Medicine, 318, 13491354.Google Scholar
Courchesne, E., Townsend, J. & Saitoh, O. (1994) The brain in infantile autism: posterior fossa structures are abnormal. Neurology, 44, 214223.Google Scholar
Damasio, A. R., Maurer, R. G., Damasio, A. R., et al (1980) Computerised tomographic scan findings in patients with autistic behaviour. Archives of Neurology, 37, 504510.CrossRefGoogle Scholar
Deb, S. (1997a) Structural neuroimaging in learning disability. British Journal of Psychiatry, 171, 417419.Google Scholar
Deb, S. (1997b) Behavioural phenotypes. In Psychiatry in Learning Disability (ed. Read, S.), pp. 93116. London: W B. Saunders.Google ScholarPubMed
De Volder, A., Bol, A., Michel, C., et al (1987) Brain glucose metabolism in children with the autistic syndrome: Positron tomography analysis. Brain Development, 9. 581587.Google Scholar
Ellis, H. D., Ellis, D. M., Fraser, W., et al (1994) A preliminary study of right hemisphere cognitive deficits and impaired social judgments among young people with Asperger syndrome. European Child and Adolescent Psychiatry, 3. 255266.Google Scholar
Filipek, P. A., Richelme, C., Kennedy, D. N., et al (1992) Morphometric analysis of the brain in developmental language disorders and autism. Annals of Neurology, 32, 475.Google Scholar
Gaffney, G. R., Kuperman, S., Tsai, L. Y., et al (1987) Midsagittal magnetic resonance imaging of autism. British Journal of Psychiatry, 151, 831833.Google Scholar
Garber, H. J. & Ritvo, E. R. (1992) Magnetic resonance imaging of the posterior fossa in autistic adults. American Journal of Psychiatry, 149, 245247.Google ScholarPubMed
Gillberg, C. I. & Svendsen, P. (1983) Childhood psychosis and computed tomography brain scan findings. Journal of Autism and Developmental Disorders, 13, 1932.CrossRefGoogle Scholar
Gillberg, C. I., Bjure, J., Uvebrant, P., et al (1993) SPECT (single photon emission computed tomography) in 31 children and adolescents with autism and autistic-like conditions. European Child and Adolescent Psychiatry, 2, 5059.Google Scholar
Hashimoto, T., Tayama, M., Murakawa, M., et al (1995) Development of the brainstem and cerebellum in autistic patients. Journal of Autism and Developmental Disorders, 25, 118.Google Scholar
Hauser, S. L., DeLong, G. R. & Rosman, N. P. (1975) Pneumographic findings in the infantile autism syndrome: a correlation with temporal lobe disease. Brain, 98, 667688.Google Scholar
Haznedar, M. M., Buchsbaum, M. S. & Metzger, M. (1997) Anterior cingulate gyrus volume and glucose metabolism in autistic disorder. American Journal of Psychiatry, 154, 10471050.Google ScholarPubMed
Herold, S., Frackowiak, R. S. J., Le Conteur, A., et al (1988) Cerebral blood flow and metabolism of oxygen and glucose in young autistic adults. Psychological Medicine, 18, 823831.CrossRefGoogle ScholarPubMed
Holttum, J. R., Minshew, N. J., Sanders, R. S., et al (1992) Magnetic resonance imaging of the posterior fossa in autism. Biological Psychiatry, 32, 10911101.Google Scholar
Horwitz, B., Rumsey, J. M., Grady, C. L., et al (1988) The cerebral metabolic landscape in autism: intercorrelations of regional glucose utilization. Archives of Neurology, 45, 749755.CrossRefGoogle ScholarPubMed
Hsu, M., Yeung-Chourchesne, R., Courchesne, E., et of (1991) Absence of magnetic resonance evidence of pontine abnormality in infantile autism. Archives of Neurology, 48, 11601163.Google Scholar
Ozonoff, S. (1995) Executive functions in autism. In Learning and Cognition in Autism (eds Schopler, E. & Mesibov, G. B.). pp. 199219. New York: Plenum Press.CrossRefGoogle Scholar
Piven, J., Nehme, E., Simon, J., et al (1992) Magnetic resonance imaging in autism: measurement of the cerebellum, pons, and fourth ventricle. Biological Psychiatry, 31, 491504.Google Scholar
Piven, J., Arndt, S., Bailey, B. S., et al (1995) An MRI study of brain size in autism. American Journal of Psychiatry, 152, 11451149.Google Scholar
Piven, J., Bailey, J., Ranson, B. J., et al (1997) An MRI study of the corpus callosum in autism. American Journal of Psychiatry, 154, 10511056.Google Scholar
Rapin, I. & Katzman, R. (1998) Neurobiology of autism. Annals of Neurology, 43, 714.CrossRefGoogle ScholarPubMed
Rumsey, J. M., Duara, R., Grady, C., et al (1985) Brain metabolism in autism. Archives of General Psychiatry, 42, 448455.Google Scholar
Schafter, B. G., Thompson, J. N., Bodensteiner, J. B., et al (1996) Hypoplasia of the cerebellar vermis in neurogenetic syndromes. Annals of Neurology, 39, 382385.Google Scholar
Zilbovicius, M., Garreau, B., Samson, Y., et al (1995) Delayed maturation of the frontal cortex in childhood autism. American Journal of Psychiatry, 152, 248252.Google Scholar
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