Hostname: page-component-8448b6f56d-cfpbc Total loading time: 0 Render date: 2024-04-23T09:30:34.662Z Has data issue: false hasContentIssue false
  • English
  • Français

Preterm birth and intra-uterine growth retardation among children of women with schizophrenia

Published online by Cambridge University Press:  03 January 2018

B. E. Bennedsen ,
P. B. Mortensen ,
A. V. Olesen  and
T. B. Henriksen
B. E. Bennedsen*
Affiliation:
Department of Psychiatric Demography, Institute for Basic Psychiatric Research, Psychiatric Hospital in Aarhus, University Hospital in Aarhus, Risskov, Denmark
P. B. Mortensen
Affiliation:
Department of Psychiatric Demography, Institute for Basic Psychiatric Research, Psychiatric Hospital in Aarhus, University Hospital in Aarhus, Risskov, Denmark
A. V. Olesen
Affiliation:
Department of Psychiatric Demography, Institute for Basic Psychiatric Research, Psychiatric Hospital in Aarhus, University Hospital in Aarhus, Risskov, Denmark
T. B. Henriksen
Affiliation:
Perinatal Research Unit, Skejby Sygehus, University Hospital in Aarhus, Århus N, Denmark
*
B. E. Bennedsen, Department of Psychiatric Demography, Institute for Basic Psychiatric Research, Psychiatric Hospital in Aarhus, 8240 Risskov, Denmark
Get access Rights & Permissions [Opens in a new window]

Abstract

Background

There is conflicting evidence about the frequency of adverse pregnancy outcomes among women with schizophrenia.

Aims

To investigate the risk of preterm birth, low birth weight and intra-uterine growth retardation among women with schizophrenia.

Method

A total of 2212 births to 1537 women with schizophrenia in Denmark were compared with a random sample of all deliveries in Denmark in 1973–1993 (122 931 births to 72 742 women)

Results

The children of women with schizophrenia were at increased risk of preterm delivery (relative risk=1.46, 95% CI=1.19–1.79), low birth weight (relative risk=1.57, 95% 0=1.36–1.82) and small for gestational age (relative risk=1.34, 95% CI=1.17–1.53)

Conclusions

Women with schizophrenia are at increased risk of adverse pregnancy outcome. This may be associated with an increased mortality and general morbidity and risk of schizophrenia in their children.

Type
Papers
Information
The British Journal of Psychiatry , Volume 175 , Issue 3 , September 1999 , pp. 239 - 245
Copyright
Copyright © 1999 The Royal College of Psychiatrists 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Aliebeck, P., Adamsson, C., Engstrom, A., et al (1993) Cannabis and schizophrenia: a longitudinal study of cases treated in Stockholm County. Acta Psychiatrica Scandinavica, 88, 21–24.CrossRefGoogle Scholar
Ananth, C. V., Savitz, D. A. (1994) Vaginal bleeding and adverse reproductive outcomes: a meta-analysis. Paediatric and Perinatal Epidemiology, 8, 62–78.CrossRefGoogle ScholarPubMed
Ariyuki, Y., Hata, T. & Kitao, M. (1995) Evaluation of perinatal outcome using individualized growth assessment: comparison with conventional methods. Pediatrics, 96, 36–42.Google Scholar
Bennedsen, B. (1998) Adverse pregnancy outcome in schizophrenic women: occurrence and risk factors. Schizophrenia Research, 33, 1–26.CrossRefGoogle ScholarPubMed
Cnattingius, S., Formen, M. R., Berendes, H. W., et al (1993) Effect of age, parity, and smoking on pregnancy outcome: a population-based study. American Journal of Obstetrics and Gynecology 168, 16–21.Google Scholar
Colley, N. V., Tremble, J. M., Hanson, G. L., et al (1991) Head circumference/abdominal circumference ratio, ponderal index and fetal malnutrition. Should head circumference/abdominal circumference ratio be abandoned? British Journal of Obstetrics and Gynaecology 98, 524–527.CrossRefGoogle ScholarPubMed
Dohrenwend, B. P. & Schwartz, S. (1995) Socioeconomic status and psychiatric disorders. Current Opinion in Psychiatry, 8, 138–141.Google Scholar
Fish, B., Marcus, J., Hans, S. L., et al (1992) Infants at risk for schizophrenia: sequelae of a genetic neurointegrative defect. A review and replication analysis of pandysmaturation in the Jerusalem Infant Development Study. Archives of General Psychiatry 49, 221–235.Google Scholar
Goodman, S. H. & Emory, E. K. (1992) Perinatal complications in births to low socioeconomic status schizophrenic and depressed women. Journal of Abnormal Psychology 101, 225–229.Google Scholar
Gottesman, I. I. (1991) Schizophrenia Genesis. The Origins of Madness. New York: W. H. Freeman.Google Scholar
Hultman, C. M., Sparen, P., Takel, N., et al (1999) Prenatal and perinatal risk factors for schizophrenia, affective psychosis, and reactive psychosis of early onset: case–control study. British Medical Journal. 318, 421–426.Google Scholar
Jones, P. B., Rantakallio, P., Hartikainen, A. L. et al (1998) Schizophrenia as a long-term outcome of pregnancy, delivery, and perinatal complications: a 28-year follow-up of the 1966 north Finland general population birth cohort. American Journal of Psychiatry, 155, 355–364.CrossRefGoogle ScholarPubMed
Knudsen, L. B. (1993) Information on parity in the medical registry of births of the National Board of Health. Validation with the help of a new fertility database in Danish Statistics. Ugeskrift for Laeger, 155, 2525–2529.Google Scholar
Kramer, M. S. (1987) Determinants of low birth weight: methodological assessment and meta-analysis. Bulletin of World Health Organization. 65, 663–737.Google Scholar
Kristensen, J., Langhoff-Roos, J., Skovgaard, L. T., et al (1996) Validation of the Danish Birth Registration. Journal of Clinical Epidemiology, 49, 893–897.Google Scholar
Lier, L., Kastrup, M. & Rafaelsen, O. J. (1989) Psychiatric illness in relation to pregnancy and childbirth. II. Diagnostic profiles, psychosocial and perinatal aspects. Nordisk Psykiatrisk Tidsskrift, 43, 535–542.CrossRefGoogle Scholar
Marcelis, M., van Os, J., Sham, P., et al (1998) Obstetric complications and familial morbid risk of psychiatric disorders. American Journal of Medical Genetics, 81, 29–36.Google Scholar
McCormick, M. C. (1985) The contribution of low birth weight to infant mortality and childhood morbidity. New England Journal of Medicine. 312, 82–90.CrossRefGoogle ScholarPubMed
McNeil, T. F. (1991) Obstetric complications in schizophrenic parents. Schizophrenia Research, 5, 89–101.Google Scholar
McNeil, T. F. & Kaij, L. (1973) Obstetric complications and physical size of offspring of schizophrenic, schizophrenic-like, and control mothers. British Journal of Psychiatry, 123, 341–348.Google Scholar
Munk-Jergensen, P. (1995) Faldende førstegangsindlæggelsesrater for skizofreni i Danmark 1790–1991 [Decreasing first admission rates for schizophrenia in Denmark 1970–1991] [Thesis]. Risskov: Department of Psychiatric Demography.Google Scholar
Munk-Jergensen, P. & Morteneen, P. B. (1997) The Danish Psychiatric Central Register. Danish Medical Bulletin, 44, 82–84.Google Scholar
Patterson, R. M. & Poullot, M. R. (1907) Neonatal morphometrics and perinatal outcome: who is growth retarded? American Journal of Obstetrics and Gynecology 157, 691–693.Google Scholar
Ragins, N., Schacter, J., Elmer, E., et al (1975) Infants and children at risk for schizophrenia. Journal of Child Psychiatry 14, 150–177.Google Scholar
Sackar, A., Dona, D. J. & Crow, T. J. (1996) Obstetric complications in children born to parents with schizophrenia: a meta-analysis of case–control studies. Psychological Medicine, 26, 279–287.Google Scholar
Sanderson, D. A. Wilcox, M. A. & Johnson, I. R. (1994) The individualised birthweight ratio: a new method of identifying intrauterine growth retardation. British Journal of Obstetrics and Gynaecology 101, 310–314.Google Scholar
SAS Institute (1996) SAS Proprietary Software (release 6.12). Cary. NC: SAS Institute.Google Scholar
Stokes, M. E. Devis, C. S. & Koch, G. G. (1995) Categorical Data Analysis Using the SAS System. Cary. NC: SAS Institute.Google Scholar
Sundhadsstyrelsen (1987) Medicinsk fedselsstatistik 1985. [Obstetrics. Vital statistics 1985]. Copenhagen: Sundhedsstyrelsen.Google Scholar
Wen, S. W., Goldenberg, R. L., Cutter, G. R., et al (1990) Smoking, maternal age, fetal growth, and gestational age at delivery. American Journal of Obstetrics and Gynecology 162, 53–58.Google Scholar
World Health Organization (1940) International Classification of Diseases (8th revision) (ICD–8). Geneva: WHO.Google Scholar
Wrede, G., Mednick, S. A., Huttunen, M. O., et al (1900) Pregnancy and delivery complications in the births of an unselected series of Finnish children with schizophrenic mothers. Acta Psychiatrica Scandinavica, 62, 369–381.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.