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Genetic and environmental risk factors in the aetiology of illicit drug initiation and subsequent misuse in women

Published online by Cambridge University Press:  31 January 2018

Kenneth S. Kendler ,
Laura M. Karkowski ,
Linda A. Corey ,
Carol A. Prescott  and
Michael C. Neale
Kenneth S. Kendler*
Affiliation:
Department of Psychiatry and Department of Human Genetics
Laura M. Karkowski
Affiliation:
Department of Psychiatry
Linda A. Corey
Affiliation:
Department of Psychiatry
Carol A. Prescott
Affiliation:
Department of Psychiatry
Michael C. Neale
Affiliation:
Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Medical College of Virginia/Virginia Commonwealth University, Richmond, VA, USA
*
Kenneth S. Kendler, Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Medical College of Virginia/Virginia Commonwealth University, 800 East Leigh Street. PO Box 980126, Richmond. VA 23298-0126. USA
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Abstract

Background

Subsequent to initial exposure to the use of a psychoactive substance, psychoactive substance use disorder (PSUD) may or may not develop.

Aims

To investigate the relationship between the risk factors for initiation and the subsequent misuse of psychoactive substances.

Method

The lifetime history of illicit substance use and misuse was obtained by telephone interview with 1934 members of female–female twin pairs. We apply a novel model, which estimates the role of genetic and environmental risk factors that influence initiation and those specific to misuse, to three classes of illicit psychoactive substances.

Results

The individual-specific environment and family environment influenced the probability of initiation, but only individual-specific environment had an impact on the probability of subsequent misuse. Genetic factors which influence the risk of initiation and of misuse were identified.

Conclusions

Aetiological factors that influence drug initiation and subsequent misuse are correlated but not identical. Family environment is an important determinant of risk for drug experimentation. Two classes of genetic risk factors act on the liability to PSUD: those that influence the probability of initiation and those that influence the risk of misuse.

Type
Papers
Information
The British Journal of Psychiatry , Volume 175 , Issue 4 , October 1999 , pp. 351 - 356
Copyright
Copyright © 1999 The Royal College of Psychiatrists 

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Footnotes

Declaration of interest

Supported by the US National Institutes of Drug Abuse and Mental Health.

References

Akaike, H. (1987) Factor analysis and AIC. Psychometrika, 52, 317–332.CrossRefGoogle Scholar
American Psychiatric Association (1994) Diagnostic and Statistical Manual of Mental Disorders (4th edn) (DSM–IV). Washington, DC: APA.Google Scholar
Cadoret, R. J., Yates, W. R., Troughton, E., et al (1995) Adoption study demonstrating two genetic pathways to drug abuse. Archives of General Psychiatry, 52, 42 52.CrossRefGoogle ScholarPubMed
Cadoret, R. J., Yates, W. R., Troughton, E., et al (1996) An adoption study of drug abuse/dependency in females. Comprehensive Psychiatry, 37, 88–94.CrossRefGoogle ScholarPubMed
Cohen, J. (1960) A coefficient of agreement for nominal scales. Educational and Psychological Measurement, 20, 37–46.CrossRefGoogle Scholar
Comings, D. E., Muhleman, D., Gade, R., et al (1997) Cannabinoid receptor gene (CNRI): association with IV drug use. Molecular Psychiatry, 2, 161–168.CrossRefGoogle Scholar
Dinwiddie, S. H. & Reich, T. (1993) Genetic and family studies in psychiatric illness and alcohol and drug dependence. Journal of Addictive Diseases, 12, 17–27.CrossRefGoogle ScholarPubMed
Eaves, L. J., Eysenck, H. J., Martin, N. G., et al (1989) Genes, Culture and Personality: an Empirical Approach. London: Academic Press.Google Scholar
Jang, K. L., Livesley, W. J. & Vernon, P. A. (1995) Alcohol and drug problems: a multivariate behavioural genetic analysis of co-morbidity. Addiction, 90, 1213–1221.CrossRefGoogle ScholarPubMed
Johnson, B. A. (1990) Psychopharmacological effects of cannabis. British Journal of Hospital Medicine, 43, 117–121.Google ScholarPubMed
Kendler, K. S. (1993) Twin studies of psychiatric illness: current status and future directions. Archives of General Psychiatry, 50, 905–915.CrossRefGoogle ScholarPubMed
Kendler, K. S., Heath, A. C., Martin, N. G., et al (1987) Symptoms of anxiety and symptoms of depression: same genes, different environments? Archives of General Psychiatry, 44, 451–457.CrossRefGoogle ScholarPubMed
Kendler, K. S., Neale, M. C., Kessler, R. C., et al (1992) A population-based twin study of major depression in women: the impact of varying definitions of illness. Archives of General Psychiatry, 49, 257–266.CrossRefGoogle ScholarPubMed
Kendler, K. S., & Prescott, C. A. (1998a) Cannabis use, abuse and dependence in a population-based sample of female twins. American Journal of Psychiatry, 155, 1016–1022.CrossRefGoogle Scholar
Kendler, K. S., & Prescott, C. A. (1998b) Cocaine use, abuse and dependence in a population-based sample of female twins. British Journal of Psychiatry, 173, 345–350.CrossRefGoogle Scholar
Kendler, K. S., & Prescott, C. A. (1999a) A population-based twin study of lifetime major depression in men and women. Archives of General Psychiatry, 56, 39–44.CrossRefGoogle ScholarPubMed
Kendler, K. S., Neale, M. C., Sullivan, P. F., et al (1999b) A population-based twin study in women of smoking initiation and nicotine dependence. Psychological Medicine, 29, 299–308.CrossRefGoogle ScholarPubMed
Kendler, K. S., Karkowski, L. M. & Prescott, C. A. (1999c) Hallucinogen, opiate, sedative and stimulant use and abuse in a population-based sample of female twins. Acta Psychiatrica Scandinavica, 99, 368–376.CrossRefGoogle Scholar
Koob, G. F. & Le Moal, M. (1997) Drug abuse: hedonic homeostatic deregulation. Science, 278, 52–57.CrossRefGoogle Scholar
Lyons, M. J., Toomey, R., Meyer, J. M., et al (1997) How do genes influence marijuana use? The role of subjective effects. Addiction, 92, 409–417.CrossRefGoogle ScholarPubMed
Mirin, S. M., Weiss, R. D., Sollogub, A., et al (1984) Psychopathology in families of drug abusers. In Substance Abuse and Psychopathology (ed. Mirin, S. M.), pp. 79–106. Washington, DC: American Psychiatric Association Press.Google Scholar
Neale, M. C. (1994) Mx: Statistical Modeling (2nd edn). Richmond, VA: Medical College of Virginia/Virginia Commonwealth University Department of Psychiatry.Google Scholar
Neale, M. C. & Cardon, L. R. (1992) Methodology for Genetic Studies of Twins and Families. Dordrecht, The Netherlands: Kluwer Academic Publishers.CrossRefGoogle Scholar
Newcomb, M. & Bender, P. M. (1990) Antecedents and consequences of cocaine use: an eight-year study from early adolescence to young adulthood. In Straight and Devious Pathways from Childhood to Adulthood (eds Robins, L. & Rutter, M.), pp. 158–181. New York: Cambridge University Press.Google Scholar
Pedersen, N. L. (1981) Twin similarity for usage of common drugs. In Twin Research 3: Epidemiological and Clinical Studies, Volume 69C (eds Gedda, L., Parisi, P. & Nance, W. E.), pp. 53–59. New York: Alan R. Liss.Google Scholar
Perera, F. P. (1997) Environment and cancer: who are susceptible? Science, 278, 1068–1073.CrossRefGoogle ScholarPubMed
Rounsaville, B. J., Kosten, T. R., Weissman, M. M., et al (1991) Psychiatric disorders in relatives of probands with opiate addiction. Archives of General Psychiatry, 48, 33–12.CrossRefGoogle ScholarPubMed
Spence, J. E., Corey, L. A., Nance, W. E., et al (1988) Molecular analysis of twin zygosity using VNTR DNA probes. American Journal of Human Genetics, 43, A159.Google Scholar
Spitzer, R. L., Williams, J. B. & Gibbon, J. (1987) Structured Clinical Interview for DSM–III–R – Patient Version (SCID–P). New York: New York State Psychiatric Institute.Google Scholar
True, W., Heath, A. C., Scherrer, J. F., et al (1997) Genetic and environmental contributions to smoking. Addiction, 92, 1277–1287.CrossRefGoogle ScholarPubMed
Tsuang, M. T., Lyons, M. J., Eisen, S. A., et al (1996) Genetic influences on abuse of illicit drugs: a study of 3297 twin pairs. American Journal of Medical Genetics, 67, 473–477.3.0.CO;2-L>CrossRefGoogle Scholar
Wentland, E. J. & Smith, K. W. (1993) Survey Responses. an Evaluation of Their Validity. San Diego: Academic Press.Google Scholar
Williams, L. J. & Holahan, P. J. (1994) Parsimony-based fit indices for multiple-indicator models: do they work? Structural Equation Modeling, 1, 161–189.CrossRefGoogle Scholar
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