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Authors' reply

Published online by Cambridge University Press:  02 January 2018

G. Dom
Affiliation:
Psychiatric Centre Alexian Brothers, Provinciesteenweg 408, 2530 Boechout, Belgium. E-mail: geert.dom@fracarita.org
B. Sabbe
Affiliation:
Collaborative Antwerp Psychiatric Research Institute, University of Antwerp, Belgium
W. Hulstijn
Affiliation:
Collaborative Antwerp Psychiatric Research Institute, University of Antwerp, Belgium
W. van den Brink
Affiliation:
Academic Medical Centre and Amsterdam Institute for Addiction Research, Amsterdam, The Netherlands
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Abstract

Type
Columns
Copyright
Copyright © Royal College of Psychiatrists, 2006 

The findings of Bowden-Jones et al (2005) add to the accumulating evidence that impairments on decision-making tasks are an important characteristic of people with substance use and possibly other addictive disorders. The finding that those alcohol-dependent people that performed poorly on behavioural tasks were at higher risk of relapse is a nice demonstration of the ‘myopia’ for the future that is reflected by poor task performance. This is in line with other recent studies, including that of Goudriaan et al (Reference Goudriaan, Oosterlaan and de Beurs2006), which showed that relapse among gamblers was associated with behavioural (but not self-reported) measures of impulsivity. Furthermore, Paulus et al (Reference Paulus, Tapert and Schuckit2005) reported that methamphetamine-dependent people with low prefrontal activation during a decision-making task relapsed significantly more frequently than those with greater activation. Together with the results of Bowden-Jones et al (2005), these findings represent an important new line of investigation.

Identification of distinctive neurobehavioural characteristics may allow detection of those people with addictions that are more vulnerable to relapse. Neurobehavioural (endophenotypic) characteristics may prove to be better for the identification of high-risk patients than traditional clinical (phenotypical) variables.

References

Goudriaan, A. E., Oosterlaan, J., de Beurs, E., et al (2006) Neurocognitive functions in pathological gambling: a comparison with alcohol dependence, Tourette syndrome and normal controls. Addiction, 101, 534547.Google Scholar
Paulus, M. P., Tapert, S. F. & Schuckit, M. A. (2005) Neural activation patterns of methamphetamine-dependent subjects during decision making predict relapse. Archives of General Psychiatry, 62, 761768.CrossRefGoogle ScholarPubMed
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