In their comparative epidemiological study of chronic fatigue syndrome in Brazil and London, Cho et al ^{Reference Cho, Menezes, Hotopf, Bhugra and Wessely1} conclude that cultural differences affect only the recognition, rather than occurrence, of this condition. Although a reasonable interpretation of the epidemiological data, without complementary consideration of the cultural context this assertion is likely to obscure some of the most salient features and clinical significance of the study. The authors note that ‘both population and healthcare professionals seem unfamiliar with the construct of the syndrome.’ Recognition of the community and professional inattention to and low priority of chronic fatigue syndrome, however, is not necessarily a failing; it may also be regarded as an updated example of Kleinman's ^{Reference Kleinman2} formulation of the category fallacy – the imposition of alien diagnostic concepts where they lack local validity. The assertion of underrecognition is incomplete without consideration of alternative formulations of the problems that in some respects resemble the syndrome, but are not diagnosed. Do conditions such as neurasthenia in East Asia and dhat syndrome in South Asia have characteristic patterning of distress or meaning in Brazil?

If one accepts the authors' tacit premise that the constructs of chronic fatigue syndrome and related UK formulations (encephalomyelitis and fibromyalgia) are unquestionably valid diagnoses for use everywhere, then the conclusion that chronic fatigue syndrome is neglected by professionals but no less important in the Brazilian population is valid. Accepting that premise, however, requires that we ignore the fact that the syndrome is neither in the ICD or DSM, and neurasthenia was rejected after consideration in the draft version of DSM–IV. ^{Reference Paralikar, Sarmukaddam, Agashe and Weiss3} Standard texts in the field of cultural psychiatry regard chronic fatigue syndrome as a North American culture-bound syndrome. ^{Reference Griffith, Gonzalez, Blue, Hales and Yudofsky4} Earlier research by some of the same Brazilian authors also highlights the social determinants of essential features of chronic fatigue, rather than the categorical diagnosis of the syndrome. ^{Reference de Fatima Marinho de Souza, Messing, Menezes and Cho5}

Culturally sensitive clinical care will benefit from a reconsideration of cultural interpretations of these study data and from additional cross-cultural research. Are other diagnoses or local clinical and cultural formulations used to manage and treat such patients locally? Are other non-medical sources of help and social interventions given higher priority by patients and communities in Brazil?

Findings of Karasz & McKinley ^{Reference Karasz and McKinley6} showing the tendency of North Americans to ‘medicalise’ and South Asians to ‘socialise’ similar clinical vignettes recommend consideration of that point. Among patients studied by Cho et al, one might also ask whether higher rates of associated common mental disorders suggest that these psychiatric conditions are more likely to be the focus of treatment. The emphasis on underrecognition of chronic fatigue syndrome is likely to prove less important for community mental health and culturally sensitive care than questions of how such clinical patterns are understood in the population and explained by professionals.