The British Journal of Psychiatry
ENCODE and a new landscape for psychiatric genetics
Akshay Nair, Robert Howard
  • Declaration of interest

    None.

Abstract

Despite rigorous research into the genetics of neuropsychiatric disorders, the mechanism by which polygenic risk leads to complex clinical phenotypes remains unclear. The Encyclopedia of DNA Elements (ENCODE) project gives us new insight into gene regulation, and gene-gene and gene-environment interaction. Better understanding of these key genomic mechanisms may provide the answers we have been searching for.

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