The British Journal of Psychiatry
The 25th anniversary of the launch of Prozac gives pause for thought: where did we go wrong?
Edward Shorter
  • Declaration of interest



The creation, in DSM-III, of the category ‘major depression’ can be linked to the launch, and success, of Prozac. The consequences of creating this broad diagnostic category are of concern in relation to the treatment of individuals with a diverse variety of depressive disorders.

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