The British Journal of Psychiatry
ANK3 gene expression in bipolar disorder and schizophrenia
Katrine Verena Wirgenes, Martin Tesli, Elin Inderhaug, Lavinia Athanasiu, Ingrid Agartz, Ingrid Melle, Timothy Hughes, Ole Andreas Andreassen, Srdjan Djurovic
  • Declaration of interest



ANK3 gene variants have consistently been associated with bipolar spectrum disorder and schizophrenia spectrum disorder. However, the relevance of its encoded protein, ankyrin-3, in these disorders remains elusive. Here, we show that ANK3 gene expression in blood is significantly increased in bipolar disorder and schizophrenia compared with healthy controls. Additionally, we identified potential cis-acting expression quantitative trait loci located close to the transcription start site of one of the isoforms of the gene. These findings suggest that ANK3 mRNA is an interesting marker for further investigation of the underlying mechanisms in psychotic disorders.


  • Funding

    The work was supported by the Research Council of Norway, the South-East Norway Regional Health Authority and KG Jebsen Foundation.

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