Declaration of interest
G.J.D and J.W.G. receive material support from Neuronetics. J.W.G. has received speaker fees to discuss TMS at professional conferences from Neuronetics and grant support from Astra Zeneca, Bristol-Myers Squibb, Eli Lilly, Eisai, Forest, Hoffmann-La Roche, Janssen, Johnson & Johnson, Merck/Schering-Plough, Neuronetics, Neosync, Novartis, Otsuka, Pfizer, Shire Sunovion, Takeda and Teva. D.F.T. receives funding from Palo Alto Health Sciences.
Repetitive transcranial magnetic stimulation (rTMS) holds promise for treating generalised anxiety disorder (GAD) but has only been studied in uncontrolled research.
Twenty five participants (active n = 13; sham, n = 12) enrolled. rTMS was targeted at the right dorsolateral prefrontal cortex (DLPFC, 1 Hz, 90% resting motor threshold).
Response and remission rates were higher in the active v. sham groups and there were significant group × time interactions for anxiety, worry and depressive symptoms, favouring active v. sham. In addition, right DLPFC activation during a decision-making gambling task increased at post-treatment for active rTMS only, and changes in neuroactivation correlated significantly with changes in worry symptoms.
Findings provide preliminary evidence that rTMS may improve GAD symptoms in association with modifying neural activity in the stimulation site.
↵* Data from this study were presented at the annual meeting of the American Psychiatric Association New York, May 2014 and the meeting of the Society for Biological Psychiatry, New York, May 2014.
This study was funded by a grant (number: 129522) from the Hartford HealthCare Research Funding Initiative to G.J.D. The funding source had no role in the study design; collection, analysis, interpretation of data; writing the report, or in making the decision to submit the article for publication. Material support was provided by Neuronetics. Neuronetics reviewed a draft of this report prior to submission and otherwise had no role in the study design; collection, analysis, interpretation of data; writing the report, or in making the decision to submit the article for publication.
- © The Royal College of Psychiatrists 2016.
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