Declaration of interest
P.P. received speaker fees from Jansen-Cilag.
Sponsorship bias has never been investigated for non-pharmacological treatments like psychotherapy.
We examined industry funding and author financial conflict of interest (COI) in randomised controlled trials directly comparing psychotherapy and pharmacotherapy in depression.
We conducted a meta-analysis with subgroup comparisons for industry v. non-industry-funded trials, and respectively for trial reports with author financial COI v. those without.
In total, 45 studies were included. In most analyses, pharmacotherapy consistently showed significant effectiveness over psychotherapy, g = −0.11 (95% CI −0.21 to −0.02) in industry-funded trials. Differences between industry and non-industry-funded trials were significant, a result only partly confirmed in sensitivity analyses. We identified five instances where authors of the original article had not reported financial COI.
Industry-funded trials for depression appear to subtly favour pharmacotherapy over psychotherapy. Disclosure of all financial ties with the pharmaceutical industry should be encouraged.
- © The Royal College of Psychiatrists 2017.
Log in using your username and password
Log in through your institution
Purchase Short-Term Access
Pay per Article - You may access this article (and download the PDF version) for 1 day for US$30.00.
Pay per Issue - You may access this issue (from the computer you are currently using) for 365 days for US$90.00.
Pay for Admission - You may access all content in The British Journal of Psychiatry (and download the PDF version) for 1 day for US$45.00.
Regain Access - You can regain access to a recent Pay per Article, Pay per Issue, or Pay for Admission purchase if your access period has not yet expired.