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Behavioural activation for depression in older people: systematic review and meta-analysis

Published online by Cambridge University Press:  02 January 2018

Vasiliki Orgeta*
Affiliation:
Division of Psychiatry, University College London, UK
Janina Brede
Affiliation:
Division of Psychiatry, University College London, UK
Gill Livingston
Affiliation:
Division of Psychiatry, University College London, UK
*
Dr Vasiliki Orgeta, Division of Psychiatry, University College London, 6th Floor, Maple House, 149 Tottenham Court Road, London W1T 7NF, UK. Email: v.orgeta@ucl.ac.uk
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Abstract

Background

Behavioural activation is an effective treatment for depression in the general adult population but it is unclear whether it is effective for older people.

Aims

To systematically review randomised controlled trials (RCTs) of behavioural activation for depression in older people.

Method

We searched Medline, EMBASE, PsycINFO, CINAHL and online trial registers for RCTs of behavioural activation for depression in older people.

Results

Eighteen trials were included in the meta-analyses. Behavioural activation reduced mean depression scores for older people living in the community as a stand-alone treatment: standardised mean difference (SMD) −0.72, 95% Cl −1.04 to −0.41. It was also effective as part of a multicomponent intervention (SMD −0.44, 95% CI −0.56 to −0.32).

Conclusions

Behavioural activation significantly reduces depressive symptoms in older people in the community; however, given that most studies are small and with significant bias results should be interpreted with caution. Further high-quality trials of behavioural activation for this age group are needed.

Type
Review article
Copyright
Copyright © The Royal College of Psychiatrists 2017 

Depression in older people is a prevalent and disabling condition, with major depressive disorder affecting approximately 5–15% of older people living in the community. Reference Rodda, Walker and Carter1 Estimates of prevalence of mild symptoms of depression, often referred to as subsyndromal depression, are much higher, ranging from 5% to 37%. Reference Meeks, Vahia, Lavretsky, Kulkarni and Jeste2 Untreated symptoms – even when mild – can contribute to poor physical and psychiatric outcomes such as increasing the number and severity of episodes of medical illness and the risk of developing major depression. Reference Koenig3 Depression diminishes older adults' quality of life, exacerbates functional deficits and increases risk of morbidity and mortality. Reference Schoevers, Geerlings, Beekman, Penninx, Deeg and Jonker4 It is the major contributor to poor outcomes in older people, and contributes heavily to healthcare costs. Reference Vasiliadis, Dionne, Preville, Gentil, Berbiche and Latimer5 Depression in late life is often underdetected and untreated, Reference Rodda, Walker and Carter1 and may be resistant to antidepressant therapy. Reference Knochel, Alves, Friedrichs, Schneider, Schmidt-Rechau and Wenzler6 Many studies of psychological treatments have few or no older participants. It is estimated that preventing and treating depressive symptoms in older people may result in significantly reduced healthcare use and in cost savings. Reference Smit, Ederveen, Cuijpers, Deeg and Beekman7 With an increasingly ageing population it is important to find out what strategies are effective for managing depression in older people and addressing the needs of those with cognitive impairment. Behavioural explanations of low mood and depressive affect are rooted in learning theory models of depression, which argue that increasing positively reinforcing behaviours leads to more positive consequences for individuals, thereby improving mood. Reference Lewinsohn, Hoberman, Teri, Hautzinger, Reiss and Bootzin8 The lack of events associated with positive outcomes in the person's environment is a key contributor to the emergence or maintenance of depressive symptoms. Reference Lewinsohn, Munoz, Youngren and Zeis9 According to behavioural models of depression in late life, Reference Fiske, Wetherell and Gatz10 depressive symptoms may be intensified or maintained by the absence of positive feelings resulting from participation in enjoyable and meaningful activity. Interventions that target activities may therefore theoretically be particularly helpful in preventing or treating depression in older people. Behavioural activation is an effective treatment for depression for adults, with recent studies indicating that it is as effective as cognitive-behavioural therapy (CBT) and potentially less costly. Reference Richards, Ekers, McMillan, Taylor, Byford and Warren11 Despite evidence of clinical effectiveness in younger adults, evidence of effectiveness in older people is less clear. Although there are several studies evaluating behavioural activation in older people, there is no systematic review bringing the evidence together. Our aim was to evaluate worldwide evidence on the clinical effectiveness of behavioural activation for depression in older people and report on its quality.

Method

We searched all related behavioural activation and behaviour therapy terms in Medline, EMBASE, CINAHL, PsycINFO and the Cochrane library for ongoing trials, national and international trial registers, and specialised databases of psychological treatments of depression (www.evidencebasedpsychotherapies.org) to December 2016 (see online supplement DS1 for details of search terms). We scanned reference lists of all included studies and 136 reviews relevant to the area identified by the search (psychological therapies in older people with or without cognitive impairment or dementia).

Inclusion criteria were as follows. Studies had to be randomised controlled trials (RCTs) comparing behavioural activation with treatment as usual (or any other treatment); samples comprised older people (at least 55 years old) in any setting (community, in-patient or long-term care) and included participants with or without cognitive impairment or dementia. Outcomes were either depressive symptom score or depression remission. Secondary outcomes were function, quality of life and anxiety symptoms.

We defined behavioural activation as a brief, structured psychotherapeutic approach that aimed to increase engagement in adaptive activities (often associated with pleasure and mastery) through structured activity scheduling and monitoring of mood (association of mood and activities), and/or other behavioural strategies such as relaxation and stress reduction techniques, social skills enhancement or hierarchical construction of goals. Reference Dimidjian, Barrera, Martell, Munoz and Lewinsohn12 Some studies also included additional interventions. Activity interventions that did not satisfy these criteria or had a large exercise component were defined as behavioural activation-related. We divided interventions according to where they took place (community, in-patient/24 h care settings, care homes) and by short-term (4–12 weeks) or long-term (8–12 months) effectiveness. We also tested whether publication bias was present.

Two reviewers (V.O. and J.B.) worked independently to identify RCTs that met the inclusion criteria, and extracted data independently. Disagreements were discussed with the third author (G.L.). We contacted authors of primary trials if there were missing data. We employed the Cochrane Handbook for Systematic Reviews of Interventions approach for assessing risk of bias, addressing the domains of sequence generation, allocation concealment, masking, incomplete outcome data, selective reporting and other issues (www.handbook.cochrane.org).

Statistical analysis

We used a random effects model to represent overall estimate effects, and standardised mean differences (SMDs) when studies used different outcome scales. We quantified heterogeneity using the I 2 statistic. All calculations were conducted using Review Manager (RevMan 5.2) for Windows. We used the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach to summarise overall quality of evidence (www.gradeworkinggroup.org), and performed a sensitivity meta-analysis on high-quality studies only.

Results

We identified 7248 references through database searching, with 33 additional references identified through other sources (Fig. 1). After removal of duplicates and clearly irrelevant articles, we retrieved 391 full-text records. Of these, 327 were excluded at this stage as not relevant, leaving 64 full-text references to be fully assessed for eligibility. Of these, 36 studies were excluded as not meeting inclusion criteria: they evaluated behavioural activation in family carers (8 studies); were not RCTs (14 studies); the intervention did not fulfil our criteria of behavioural activation (12 studies); there was no control comparison group (1 study); and data were not available (1 study). A total of 28 studies were eligible for inclusion, of which 7 were ongoing. Reference Farrand13Reference Dong, Chen, Wong and Simon19 The main characteristics of the studies, including descriptions of elements of interventions, are summarised in online Tables DS1 (included studies) and DS2 (excluded studies).

Fig. 1 Study flow diagram. BA, behavioural activation; RCT, randomised controlled trial.

Description of studies

We were able to pool data from 18 studies. There were nine studies in older people living in the community, three RCTs in in-patient settings and six studies in older people living in care homes, some of whom had cognitive impairment. We pooled data from five RCTs on behavioural activation only (community settings), Reference Gallagher and Thompson20Reference Scogin, Jamison and Gochneaur24 and four trials on multicomponent behavioural activation (community settings), Reference Ciechanowski, Wagner, Schmaling, Schwartz, Williams and Diehr25Reference Gilbody, Lewis, Adamson, Atherton and Bailey28 for depressive symptoms. All of the multicomponent behavioural activation studies provided data on remission of symptoms. We pooled data from all three RCTs evaluating behavioural activation in in-patient settings, Reference Norton29Reference Sood, Cisek, Zimmerman, Zaleski and Fillmore31 and all six studies of behavioural activation in older people living in care homes. Reference Dozeman, van Schaik, van Marwijk, Stek, Beekman and van der Horst32Reference Verkaik, Francke, van Meijel, Spreeuwenberg, Ribbe and Bensing37 Although there were three studies of people with dementia that aimed to increase activity, none of these met the inclusion criteria. These studies were in community-dwelling people with dementia, and evaluated interventions with a strong physical activity component, and activity scheduling was not structured; Reference Teri, Logsdon, Uomoto and McCurry38Reference Gitlin, Winter, Dennis, Hodgson and Hauck40 we classified them as behavioural activation-related. We judged these studies as too different to be pooled in a meta-analysis. We used the chi-squared test to detect and report on heterogeneity.

Primary outcomes

Depression severity

Meta-analysis of the effects of behavioural activation on depressive symptoms showed that results significantly favoured the therapy (5 studies; n = 175, SMD = −0.72, 95% CI −1.04 to −0.41, efficacy at 4–12 weeks) in reducing depressive symptoms for older people living in the community (with a diagnosis of depression or subthreshold depressive symptoms), with no heterogeneity between the studies (I 2 = 0%) (Fig. 2). Multicomponent behavioural activation reduced depressive symptoms in comparison with treatment as usual in the short term (4 studies; n = 2523, SMD = −0.44, 95% CI −0.56 to −0.32, efficacy at 3–6 months; Fig. 3) but not long-term (4 studies; n = 2300, SMD = −0.30, 95% CI −0.59 to 0.00, efficacy at 8–12 months; Fig. 4). There was moderate (I 2 = 39%) to high heterogeneity (I 2 = 88%) in both of these analyses.

Fig. 2 Forest plot of behavioural activation (all forms) v. treatment as usual for older people living in the community with a diagnosis of depression or depressive symptoms. Outcome: depressive symptoms (4–12 weeks). SMD, standardised mean difference.

Fig. 3 Forest plot of multicomponent behavioural activation v. treatment as usual for older people living in the community with a diagnosis of depression or depressive symptoms. Outcome: depressive symptoms (3–6 months). SMD, standardised mean difference.

Fig. 4 Forest plot of multicomponent behavioural activation v. treatment as usual for older people living in the community with a diagnosis of depression or depressive symptoms. Outcome: depressive symptoms (8–12 months). SMD, standardised mean difference.

Remission of symptoms

Multicomponent behavioural activation improved remission of depressive symptoms, both in the short term (4 studies; n = 2733, odds ratio (OR) = 2.66, 95% CI 1.46 to 4.87, efficacy at 3–6 months, I 2 = 81%; online Fig. DS1) and long term (3 studies; n = 2458, OR = 3.06, 95% CI 1.94 to 4.82, efficacy at 8–12 months, I 2 = 63%; online Fig. DS2).

Care setting

We found no significant difference between the intervention and treatment as usual groups for older people in psychiatric in-patient settings (3 studies; n = 74, SMD = −0.11, 95% CI −0.57 to 0.35, efficacy at 2–8 weeks, I 2 = 0%) or long-term care settings (6 studies; 302 participants with and without dementia, SMD = −0.43, 95% CI −0.87 to 0.01, efficacy at 6–12 weeks, I 2 = 65%).

Secondary outcomes

Multicomponent behavioural activation improved quality of life compared with treatment as usual (2 studies; n = 1806, SMD = 0.33, 95% CI 0.12 to 0.54, efficacy at 3–6 months, I 2 = 54%) and decreased functional disability for older people living in the community (2 studies; n = 1806, SMD = −0.24, 95% CI −0.33 to −0.15, efficacy at 3–6 months, I 2 = 0%). There was a significant effect of multicomponent behavioural activation, in comparison with treatment as usual, on reduction of anxiety symptoms in the short term (2 studies; n = 761, SMD = −0.30, 95% CI −0.44 to −0.15, efficacy at 4 months, I 2 = 0%), which was not maintained at long-term follow-up (2 studies; n = 739, SMD = −0.16, 95% CI −0.38 to 0.06, efficacy at 8–12 months, I 2 = 43%). None of the studies reported or described adverse events.

Quality of studies

Bias was detected predominantly in the domains of sequence generation and allocation concealment, with one study being at high risk in the domain of masking of outcome assessment (for detailed ratings see online Fig. DS3). We assessed publication bias with a funnel plot (online Fig. DS4) which appeared to be approximately symmetrical, indicating no association between standardised effect size and standard errors of effects, confirmed by Egger's test (t = −1.326, P = 0.203). Using the GRADE approach, we judged the overall quality of evidence of effectiveness of behavioural activation for depressive symptoms as moderate. We also considered the potential bias and overestimation of effects by running analyses only on high-quality studies as judged by predetermined criteria used in previous meta-analyses of psychotherapy trials. Reference Cuijpers, van Straten, Bohlmeijer, Hollon and Andersson41 Only studies of multicomponent behavioural activation (4 studies) and behavioural activation in care homes (3 studies) qualified to be included in the analyses: SMD = −0.40, 95% CI −0.48 to −0.32, I 2 = 48% (7 studies, n = 2676).

Discussion

We aimed to establish the most up-to-date and accurate estimate of the effectiveness of behavioural activation for older people. We also evaluated the quality of the evidence and presence of publication bias. We found that overall there was evidence of effects for this intervention in the range usually regarded as clinically significant, Reference Kirsch, Deacon, Huedo-Medina, Scoboria, Moore and Johnson42 with SMD values of 0.40–1.05 for behavioural activation alone and 0.37–0.81 for multicomponent behavioural activation, for older people living in the community. When only high-quality studies were considered the effect size was still 0.4. Five RCTs with a total of 175 participants (96 receiving behavioural activation, 79 treatment as usual) showed that this intervention reduced depressive symptoms in community-dwelling older people. These results compare favourably with studies of CBT for depression in older people, and are in line with recent data on the comparable effectiveness of behavioural activation in all adults. Reference Richards, Ekers, McMillan, Taylor, Byford and Warren11 However, given the paucity of trials and methodological limitations, there is still some uncertainty about this result. Four studies showed that multicomponent behavioural activation approaches benefit older people in the community with symptom remission in the short term and also approximately a year later. In terms of symptom reduction, multicomponent approaches were effective only in the short term, with differences no longer being significant in the longer term, indicating that effects are less stable. Further studies are required to confirm these results. Our analyses did not find that adding other care components such as case management or collaborative care adds to the effectiveness of behavioural activation approaches, similar to evidence in adult depression. 43 Only multicomponent approaches evaluated remission of symptoms. Although only a few studies were pooled for secondary outcomes, multicomponent behavioural activation improved functional outcomes, quality of life and anxiety in the short term. It will be important for future trials to assess long-term effectiveness of behavioural activation for older people as a stand-alone intervention.

Data on the effectiveness of behavioural activation in in-patient and long-term care settings did not show that it decreased depressive symptoms, but the majority of studies were small and of lower quality. We found three trials evaluating behavioural activation-related interventions for people with dementia. These studies, however, did not employ theoretically driven and structured approaches of behavioural activation, or included strong components of physical activity, thereby limiting the conclusions of effectiveness of behavioural activation per se.

We found that the studies evaluating behavioural activation for older people differed in terms of inclusion criteria. Although using broad inclusion criteria can be an advantage in producing results that are more generalisable, samples varied between people with or without a depression diagnosis and by intervention delivery (by mental health workers v. self-help). Self-help behavioural activation may be an impractical intervention for the most severely depressed people, who are particularly lacking in energy and motivation and may be restricted in going out from care settings because of concerns about self-harm. Our multicomponent behavioural activation, in-patient and long-term care meta-analyses included studies with varied participants in terms of medical comorbidity and cognitive impairment. It has been argued that the complex interaction of medical morbidity, cognitive impairment and psychological factors make depression in late life difficult to treat. Therefore our findings are important in that they suggest that behavioural activation may be able to address the complexity of preventing and treating depressive symptoms in older people.

Quality of the evidence

Risk of bias was unclear for multiple domains in some of the studies, with published information sometimes insufficient to determine risk of bias. Only the area of selective reporting was judged as low risk in all studies. Most of the studies had uncertainties on the areas of random sequence generation and allocation concealment. Applying the GRADE system we classified the quality of the evidence as moderate. Although publication bias did not have a significant effect on the results, we found that the effects of behavioural activation may be overestimated when including small studies. However, our analyses were based on a limited number of trials overall, and we were unable to conduct other sensitivity analyses because of lack of power of potential comparisons.

Limitations

This review has several limitations. The studies had relatively low age criteria, with many including adults aged 55 years and over, whereas others had a minimum age criterion of 65 years. Many participants would therefore be less likely to have the typical circumstances of older people such as multiple physical comorbidities and no longer having employment. Our test of publication bias does not provide direct evidence of absence of bias, so it is likely that the studies overestimate the true effect size of this approach. Some of the studies investigated bibliotherapy as a treatment for late-life depressive symptoms, which may limit its use in some settings. Although all studies used central components of behavioural activation such as structured pleasant activity scheduling and mood monitoring, some reported on the use of additional behavioural strategies, which limits our understanding of which specific components are important. Reference Dimidjian, Barrera, Martell, Munoz and Lewinsohn12 High heterogeneity may have contributed to our lack of group differences in some of the outcomes and the comparison with waiting-list control conditions in some of the studies may have overestimated the effects. We also could not find information on coexisting anxiety disorders. Although there was a wide range of depression severity within studies, this range may enable findings to be generalisable to a large proportion of older people who are likely to seek treatment.

Implications for practice and research

Our findings are in line with evidence that behavioural activation may be associated with medium to large effects, being observed in relatively few sessions delivered by junior mental health workers. Reference Richards, Ekers, McMillan, Taylor, Byford and Warren11 Most of the studies included an average of 8–10 sessions across all settings, implemented primarily by non-mental health specialists. We also found that behavioural activation improved other outcomes such as quality of life and functional disability, and decreased anxiety symptoms in the short term. Currently, management of late-life depression with or without cognitive impairment is limited to the prescription of antidepressants, where there may be poor adherence or inconclusive evidence of effectiveness. Reference Knochel, Alves, Friedrichs, Schneider, Schmidt-Rechau and Wenzler6,Reference Banerjee, Hellier, Dewey, Romeo, Ballard and Baldwin44 Our data show that high-quality mental healthcare for treating or preventing clinically significant symptoms of depression in older people may benefit from individualised treatments that emphasise pleasant activities. There is a need, however, for well-designed multicentre RCTs that adhere to high standards of methodology and reporting. These trials should focus on theoretically driven behavioural activation interventions. The lack of follow-up data poses limitations in terms of informing evidence-based policy about how best to deliver behavioural activation for older people, and there are no data on cost-effectiveness. Future studies should examine long-term effects. There remains a need for carefully designed studies of interventions for older people with cognitive impairment and dementia, and considering evaluation of behavioural activation separately for older people with and without cognitive impairment, as findings may differ.

Future research

On the basis of this meta-analysis we conclude that although behavioural activation may be a potentially effective treatment for mild or subthreshold symptoms and major depression in older people, evidence remains limited. Our review suggests that additional components such as care collaboration or case management may not add to effectiveness. Given the small number of RCTs and presence of bias in studies, effects associated with behavioural activation should be interpreted with caution. Future large-scale studies are necessary to establish the effectiveness of these approaches in older people.

Funding

We thank the Alzheimer's Society for their funding of the work undertaken.

Acknowledgements

We thank all the authors who provided data and further information for this review.

Footnotes

Declaration of Interest

V.O. and G.L. are principal investigators of an ongoing trial.

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Figure 0

Fig. 1 Study flow diagram. BA, behavioural activation; RCT, randomised controlled trial.

Figure 1

Fig. 2 Forest plot of behavioural activation (all forms) v. treatment as usual for older people living in the community with a diagnosis of depression or depressive symptoms. Outcome: depressive symptoms (4–12 weeks). SMD, standardised mean difference.

Figure 2

Fig. 3 Forest plot of multicomponent behavioural activation v. treatment as usual for older people living in the community with a diagnosis of depression or depressive symptoms. Outcome: depressive symptoms (3–6 months). SMD, standardised mean difference.

Figure 3

Fig. 4 Forest plot of multicomponent behavioural activation v. treatment as usual for older people living in the community with a diagnosis of depression or depressive symptoms. Outcome: depressive symptoms (8–12 months). SMD, standardised mean difference.

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