The author observed 104 general paralytics, but only 30 of these passed through the three stages, the others dying either in the first or second stage; 750 successful observations were made altogether, from which the following important conclusions among others are made by the author. The light reflex is more often abnormal than normal, and the alteration is almost invariably in the sense of diminution. Diminution and abolition were about equally frequent, and mostly the same in the two eyes. Abnormality was found in about one fourth of the admissions. Certain differences in the frequency of abnormalities were found according to the form of general paralysis, and according to the apparent aetiology. In the first two stages of the disease the light reflex was more altered in cases exhibiting motor affection. No clear relation seems to have been observed between alterations of the light reflex and sensory affections, except that diminution of tactile sensation was associated generally with some abnormality of the light reflex or its abolition. While examination of the light reflex, by revealing frequent and early alterations, is useful in the diagnosis of doubtful cases of general paralysis, it is of no assistance in prognosis.