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Changes in the Output of 17-Ketosteroids After Shock Treatment, Pre-Frontal Leucotomy, and Other Procedures

Published online by Cambridge University Press:  08 February 2018

R. E. Hemphill ,
L. D. MacLeod  and
Max Reiss
R. E. Hemphill
Affiliation:
Department of Endocrinology, Burden Neurological Institute, and Bristol Mental Hospital
L. D. MacLeod
Affiliation:
Department of Endocrinology, Burden Neurological Institute, and Bristol Mental Hospital
Max Reiss
Affiliation:
Department of Endocrinology, Burden Neurological Institute, and Bristol Mental Hospital
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Extract

The estimation of the amount of neutral 17-ketosteroids excreted in the urine has attracted considerable attention, since the level of excretion (usually expressed as mgm./24 hours) can be fairly well correlated with the output of androgenic substances determined biologically (Callow et al., 1939a, b). What constitutes the normal range of daily output is still somewhat uncertain; 1.7 to 12.6 mgm. for females, 3.5 to 15 mgm. for males (Callow, 1939), 40 to 15 for normal women (Friedgood and Whidden, 1939), 4.3 to 21 mgm. (Chou and Wang, 1939), 3.5 to 14.6 mgm. for females, 9.4 to 20.4 for males (Patterson, McPhee, Greenwood, 1942) have been quoted. We have conducted investigations in a large number of cases of each sex in the last two years, and have come to regard 6 to 15 mgm. daily as the range for normal adults, females as a rule being lower in the scale than males; after middle age a somewhat reduced output is to be expected. It has been suggested (Patterson et al., 1942) that among normals higher values are related to larger body size, but we are unable to confirm this.

Type
Part II.—Original Articles
Information
Journal of Mental Science , Volume 88 , Issue 373 , October 1942 , pp. 554 - 558
Copyright
Copyright © Royal College of Psychiatrists, 1942 

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References

Barrera, S. E., and Kalinowsky, L. (1942), Arch. Neurol. and Psychiat., 47, 2, 367.Google Scholar
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