In a previous communication to this Journal, the author described the results of three years' experience of pharmaco-electrical shock-therapy in the schizophrenic and depressive psychoses, and presented clinical and experimental evidence for an organic basis of these conditions. It was shown, firstly, that there is convincing evidence for supposing that deranged oxygen-glucose metabolism of the cerebral neurones is the essential lesion; and, secondly, that all these conditions can be classified according to their response to shock-therapy into two groups—dysoxic encephalopathy, or cerebral dysoxia, in which oxygen-metabolism is principally at fault, and which responds to anoxic shock; and dysglycolytic encephalopathy, or cerebral dysglycia, in which glucose-metabolism is at fault, and which responds to hypoglycaemic shock. The former condition is synonymous with depressive states, and the latter with schizophrenic reaction-types in the orthodox terminology.