Twenty-nine patients with residual neuropsychiatric symptoms after C.S.F. in early life were studied. The majority of the patients showed personality defects and complained of symptoms suggestive of an encephalopathy. They were backward in their studies, and had difficulties of adaptation at school and later at work. They were unstable, dependent, restricted in their interests, and showed tendencies to invalidism.
Those with a family history of instability showed severe and persistent reactions after recovery from C.S.F.
Nearly all showed tendencies to neurotic breakdown under conditions of even moderate stress.