Table 1

The clinical features of hyperphagic short stature (HSS) and Prader—Willi syndrome (PWS)

Feature HSS PWS
GH, growth hormone.
? denotes debate in the literature, or no data available.
Hyperphagia yes yes
Failure to thrive in infancy yes yes
Hypotonia in infancy yes yes
Short stature yes yes
GH insufficiency yes ?*
Learning difficulties yes yes
Self-injury/skin-picking yes yes
Hypogonadism ? yes
Characteristic face ? yes
Psychosocial disturbance yes yes
Obesity no yes
Overactivity yes no
Sleep disturbance yes yes
Genetic anomalies ? yes