Table 1

Serum concentrations of antidepressants in 50 nursing mother—infant pairs

Pair Maternal medication Dose (mg/day) Exposed to antidepressant during pregnancy and delivery % Breast-feeding (v. formula) Infant age at serum sample (weeks) Infant weight at serum sample (kg) Maternal medication concentration (ng/ml) Infant medication concentrations (ng/ml) Maternal metabolite concentration (ng/ml) Infant metabolite concentration (ng/ml)
n/o, not obtained; n/a, not available.
1 Sertraline 25 No 100 12 6.7 4 <1 4 <1
2 Sertraline 25 No 90 13 5.4 0 <1 13 <1
3 Sertraline 25 No 100 5 3.7 5 <1 20 <1
4 Sertraline 25 No 100 3 3.5 7 <1 9 <1
5a Sertraline 50 No 100 4 4.6 15 <1 39 2
6 Sertraline 50 No 100 28 7.8 18 <1 15 <1
7 Sertraline 50 No 100 16 4.4 28 <1 51 <1
8 Sertraline 50 No 100 39 9.1 15 <1 48 <1
9 Sertraline 50 No 100 10 3.7 3 <1 9 <1
10 Sertraline 50 Yes 50 4 3.4 42 <1 64 <1
11 Sertraline 50 Yes 80 6 3.9 30 <1 35 <1
12 Sertraline 50 Yes 50 6 4.7 19 <1 77 <1
13 Sertraline 50 Yes 100 60 9.6 8 <1 23 <1
14 Sertraline 50 No 100 17 7.7 6 <1 16 <1
15 Sertraline 50 Yes 100 11 5.4 30 8 50 4
16a Sertraline 75 No 50 26 8.1 19 <1 77 <1
17 Sertraline 75 No 100 17 6.3 82 <1 182 <1
18 Sertraline 75 Yes 50 5 4.1 92 <1 210 <1
19 Sertraline 100 No 100 9 4.9 45 <1 75 <1
20 Sertraline 100 No 100 2 5.5 50 <1 124 12
21 Sertraline 100 No 80 12 6.4 14 <1 27 <1
22 Sertraline 100 No 70 52 10.0 14 <1 36 <1
23 Sertraline 100 Yes 100 10 4.1 46 <1 128 <1
24a Sertraline 100 No 100 8 5.0 89 <1 265 11
25 Sertraline 100 No 50 44 7.8 64 <1 102 <1
26 Sertraline 125 No 100 14 6.8 48 <1 164 2
5b Sertraline 150 No 80 36 9.3 31 <1 61 <1
16b Sertraline 150 No 50 37 8.6 64 <1 84 <1
27 Sertraline 150 No 100 7 4.5 35 <1 120 4
28 Sertraline 150 Yes 100 8 4.7 53 2 133 2
24b Sertraline 150 No 100 19 7.3 7 <1 16 <1
29 Sertraline 150 Yes 100 3 3.7 102 <1 182 26
30 Sertraline 200 No 100 16 5.5 n/a <1 n/a <1
31 Paroxetine 5 No 100 16 5.1 <1 <1 n/a n/a
32 Paroxetine 10 No 100 3 4.6 10 <1 n/a n/a
33 Paroxetine 10 Yes 100 3 3.7 28 <1 n/a n/a
34 Paroxetine 20 Yes 100 2 4.0 42 <1 n/a n/a
35 Paroxetine 20 No 100 11 6.4 18 <1 n/a n/a
36 Paroxetine 20 No 100 12 6.4 24 <1 n/a n/a
37 Paroxetine 20 Yes 100 13 5.3 36 <1 n/a n/a
38 Paroxetine 20 No 100 14 7.8 <1 <1 n/a n/a
39 Paroxetine 20 No 100 16 4.3 38 <1 n/a n/a
40 Paroxetine 20 No 50 19 5.2 27 <1 n/a n/a
41 Paroxetine 20 No 40 19 7.3 27 <1 n/a n/a
42 Paroxetine 20 Yes 95 26 8.6 64 <1 n/a n/a
43 Paroxetine 20 No 100 4 3.0 21 <1 n/a n/a
44 Paroxetine 20 Yes 100 6 5.3 76 <1 n/a n/a
45 Paroxetine 25 Yes 100 7 4.6 84 <1 n/a n/a
46 Paroxetine 30 No 99 11 5.9 136 <1 n/a n/a
47 Fluvoxamine 100 Yes 100 8 4.7 140 <1 n/a n/a
48 Fluvoxamine 100 No 100 13 6.8 <1 <1 n/a n/a
49a Fluvoxamine 100 No 100 9 5.2 n/o <1 n/a n/a
49b Fluvoxamine 150 No 100 12 5.9 n/o <1 n/a n/a
50 Fluvoxamine 150 Yes 100 6 6.0 n/o <1 n/a n/a