Table 1

Age of onset of comorbid Axis 1 disorders occurring before or after onset of bipolar disorder

Axis 1 diagnosis Age of onset of BD (no comorbidities) (years) Onset of Axis 1 before BD Onset of Axis 1 after BD P value
Age of onset (years) Age of onset (years) BD1 Axis 12
n Age n BD Axis 1 n1 BD Axis 1 tPtP
*P<0.05;
**P<0.01;
***P<0.001. BD, bipolar disorder; OCD, obsessive—compulsive disorder; PTSD, post-traumatic stress disorder.
1.Comparing age of onset of bipolar disorder in patients with no Axis 1 disorder to age of onset of bipolar disorder in patients who developed Axis 1 disorder before bipolar disorder.
2.Comparing age of onset of bipolar disorder in patients who developed bipolar disorder before Axis 1 to age of onset in patients who developed Axis 1 before bipolar disorder.
3.Mean number of Axis 1 disorders occurring before the onset of bipolar illness is 3.01; mean number of Axis 1 disorders occurring after the onset of bipolar illness is 2.04; P=0.12.
Any Axis 1 disorder3 85 26.92 95 23.74 11.97 46 15.78 25.80 -4.74 <<0.001*** 8.50 <<0.001***
Any substance use/dependence 155 23.31 35 27.48 18.22 41 17.02 26.58 -4.79 <<0.001*** 4.01 <<0.001***
Drug use/dependence 200 23.68 19 25.84 16.73 22 14.31 24.27 -5.12 <<0.001*** 3.01 0.004**
Alcohol use/dependence 179 23.33 22 27.90 19.45 40 17.75 28.10 -3.95 0.002** 3.33 0.001***
Any impulse control disorder 234 22.85 14 27.57 19.92 12 13.58 24.08 -4.92 <<0.001*** 1.20 0.241
Any eating disorder 221 23.42 17 24.64 12.47 20 14.75 23.10 -4.05 <<0.001*** 4.36 <<0.001***
Any anxiety disorder 146 25.24 59 21.83 9.30 37 16.70 28.00 -2.80 0.006** 7.93 <<0.001***
Panic/agoraphobia 206 23.83 10 24.80 19.1 38 15.76 32.50 -2.89 0.006** 2.05 0.045*
Social phobia 217 23.62 19 20.89 10.89 14 15.75 23.50 -2.59 0.014* 5.18 <<0.001***
OCD 236 23.11 8 24.12 11.50 12 14.33 21.25 -2.40 0.027* 2.40 0.027*
PTSD 241 23.00 11 22.81 7.00 8 16.62 30.25 -1.43 0.169 4.95 <<0.001***
Simple phobia 233 22.98 21 20.38 7.66 4 15.75 27.00 -0.87 0.393 4.95 <<0.001***