Table 1

Outcome after 24 weeks of treatment (n=354)

Response Partial response Non-response
Statistics:
Test of interaction between the two treatment modalities: Wald χ 2=0.88; P < 0.349 (based on ordinal logistic regression model for group v. response, partial or non-response).
Sertraline groups v. non-sertraline groups: χ2=12.53, P < 0.001; odds ratio=0.534 (95% CI 0.347-0.835)
Exposure groups v. non-exposure groups: χ2=2.18, P=0.140; odds ratio=0.732 (95% CI 0.475-1.134)
Difference between all four groups: χ2=15.73; P=0.0013
Pairwise comparisons:
Sertraline/exposure v. placebo: χ2=12.32, P < 0.001
Sertraline/exposure v. exposure: χ2=3.57, P=0.059
Sertraline/exposure v. sertraline: χ2=0.22, P=0.640
Sertraline v. placebo: χ2=10.13, P=0.002
Sertraline v. exposure: χ2=2.20, P=0.138
Exposure v. placebo: χ2=3.01, P=0.083
Sertraline/exposure (n=88) 40 (45.5%) 21 (23.9%) 27 (30.7%)
Sertraline (n=87) 35 (40.2%) 25 (28.7%) 27 (31.0%)
Exposure/placebo (n=91) 30 (33.0%) 22 (24.2%) 39 (42.9%)
Placebo (n=88) 21 (23.9%) 18 (20.5%) 49 (55.7%)