Table 2

Primary efficacy variables: changes in Clinical Global Impression — Social Phobia (CGI—SP) severity sub-scale and Social Phobia Scale (SPS) during treatment and CGI—SP improvement sub-scale at final examination

Placebo (n=92) Sertraline and exposure therapy (n=95) Sertraline (n=93) Exposure therapy (n=92)
Mean change (s.e.) Mean change (s.e.) Change v. placebo P 95% Cl Mean change (s.e.) Change v. placebo P 95% Cl Mean change (s.e.) Change v. placebo P 95% Cl
Physician-rated: CGI sub-scale, ranges 1-7; patient-rated: SPS, range 20-100. All calculations adjusted for baseline values and country.
CGI—SP severity
Anxiety attacks 1.43 (0.16) 2.03 (0.16) 0.60 0.008 -0.16 to -1.05 1.86 (0.16) 0.43 0.057 -0.01 to -0.87 1.81 (0.16) 0.38 0.089 0.06 to -0.82
Avoidance 1.48 (0.16) 2.25 (0.16) 0.77 0.001 -0.38 to -1.21 1.99 (0.16) 0.51 0.002 -0.08 to -0.95 1.88 (0.16) 0.41 0.069 0.03 to -0.95
Performance anxiety 1.56 (0.16) 1.97 (0.16) 0.41 0.068 0.03 to -0.86 1.93 (0.16) 0.37 0.104 0.08 to -0.81 1.74 (0.16) 0.18 0.432 0.27 to -0.62
Disability 1.39 (0.15) 2.09 (0.15) 0.70 0.001 -0.27 to -1.12 1.84 (0.15) 0.45 0.038 -0.03 to -0.87 1.75 (0.15) 0.35 0.100 0.07 to -0.78
Overall severity 1.43 (0.15) 2.02 (0.15) 0.59 0.005 -0.18 to -1.00 1.82 (0.15) 0.39 0.065 0.03 to -0.80 1.43 (0.15) 0.30 0.146 0.11 to -0.71
CGI—SP improvement
Anxiety attacks 2.75 (0.14) 2.06 (0.14) 0.69 <0.001 0.36 to 1.07 2.32 (0.13) 0.44 0.024 0.06 to 0.81 2.43 (0.13) 0.32 0.096 -0.06 to 0.70
Avoidance 2.70 (0.13) 1.98 (0.13) 0.72 <0.001 0.35 to 1.09 2.34 (0.13) 0.37 0.051 -0.02 to 0.73 2.39 (0.13) 0.32 0.089 -0.05 to 0.73
Performance anxiety 2.72 (0.14) 2.19 (0.13) 0.53 0.005 0.16 to 0.90 2.40 (0.13) 0.32 0.091 -0.05 to 0.69 2.41 (0.13) 0.31 0.104 -0.7 to 0.68
Disability 2.68 (0.13) 2.10 (0.14) 0.58 0.002 0.22 to 0.95 2.26 (0.13) 0.42 0.025 0.05 to 0.79 2.37 (0.13) 0.31 0.103 -0.06 to 0.67
Global improvement 2.72 (0.13) 2.06 (0.13) 0.66 0.001 0.29 to 1.03 2.28 (0.13) 0.43 0.022 0.06 to 0.80 2.39 (0.13) 0.33 0.080 -0.04 to 0.70
SPS total score 10.43 (1.39) 15.23 (1.40) 4.80 0.016 -0.92 to -8.67 14.30 (1.40) 3.87 0.051 -0.16 to -7.17 12.05 (1.37) 1.62 0.407 -2.22 to -5.45