Table 1

In vitro binding affinities (Ki values in nM)1 of currently available atypical antipsychotics for 5-HT receptor subtypes

5-HT1a 5-HT2a 5-HT2c 5-HT3 5-HT6
Ki=inhibition constant. Modified from data based on Leysen et al, 1996.
1.The lower the Ki values, the higher the affinity for the receptor.
Clozapine 145 9.6 13 108 4
Risperidone 420 0.52 48 > 10 000 425
Olanzapine 2720 2.5 7.1 84 2.5
Quetiapine 320 96 3800 4060 NA
Sertindole 280 0.39 1.9 3200 NA