Table 3

Serum leptin levels, weight, weight gain, body mass index (BMI) and BMI gain by drug class1

Antipsychotic Leptin2 (ng/ml) Weight (kg) Weight gain (kg) BMI (kg/m2) BMI gain (kg/m2)
n Mean s.d. n Mean s.d. n Mean s.d. n Mean s.d. n Mean s.d.
1.Patients taking loxapine (n=1), pimozide (n=1) and zuclopenthixol (n=2) are not shown.
2.Differences are calculated with log-transformed leptin levels.
3.When controlling for current BMI: F=1.442; P=0.2.
Phenothiazines 26 11.30 7.92 26 71.42 14.25 23 10.22 10.36 26 25.73 3.45 23 3.58 3.43
Haloperidol 8 10.74 9.30 8 68.50 10.09 8 7.75 7.59 8 24.37 2.74 8 2.74 2.62
Clozapine 5 10.86 9.25 5 81.00 7.52 5 15.60 8.50 5 27.92 4.43 5 5.48 3.22
Olanzapine 7 26.60 20.02 7 80.57 16.31 7 14.71 11.46 7 29.46 6.28 7 5.55 4.49
Risperidone 5 5.64 3.96 5 73.60 6.23 5 7.40 5.55 5 25.30 2.37 5 2.50 1.79
ANOVA F=2.316; P=0.073 F=0.540; P=0.7 F=0.982; P=0.4 F=2.095; P=0.09 F=1.210; P=0.3